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Titolo:
Association studies of candidate genes in bipolar disorders
Autore:
Heiden, A; Schussler, P; Itzlinger, U; Leisch, F; Scharfetter, J; Gebhardt, C; Fuchs, K; Willett, M; Nilsson, L; Miller-Reiter, E; Stompe, T; Meszaros, K; Sieghart, W; Hornik, K; Kasper, S; Aschauer, HN;
Indirizzi:
Univ Vienna, Hosp Psychiat, Dept Gen Psychiat, Vienna, Austria Univ Vienna Vienna Austria Psychiat, Dept Gen Psychiat, Vienna, Austria Univ Vienna, Hosp Psychiat, Div Biochem Psychiat, Vienna, Austria Univ Vienna Vienna Austria chiat, Div Biochem Psychiat, Vienna, Austria Univ Vienna, Hosp Psychiat, Dept Social Psychiat & Evaluat Res, Vienna, Austria Univ Vienna Vienna Austria cial Psychiat & Evaluat Res, Vienna, Austria Tech Univ Vienna, Inst Stat & Wahrscheinlichkeitstheorie, Vienna, Austria Tech Univ Vienna Vienna Austria scheinlichkeitstheorie, Vienna, Austria
Titolo Testata:
NEUROPSYCHOBIOLOGY
, volume: 42, anno: 2000, supplemento:, 1
pagine: 18 - 21
SICI:
0302-282X(2000)42:<18:ASOCGI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN TRANSPORTER GENE; MANIC-DEPRESSIVE ILLNESS; NO ASSOCIATION; RECEPTOR GENE; POLYMORPHISM; SUSCEPTIBILITY; DRD3; RFLP; DAT1;
Keywords:
serotonin transporter, 5-HTT; serotonin 2a receptor, 5-HT2a; dopamine D2 receptor, DRD2; dopamine D3 receptor, DRD3; dopamine transporter, DAT1; bipolar disorder; polymorphism; association study;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Heiden, A Dept Gen Psychiat, Wahringer Gurtel 18-20, A-1090 Vienna, Austria Dept Gen Psychiat Wahringer Gurtel 18-20 Vienna Austria A-1090
Citazione:
A. Heiden et al., "Association studies of candidate genes in bipolar disorders", NEUROPSYCHB, 42, 2000, pp. 18-21

Abstract

The aim of the investigation was to test genes for predisposition to bipolar affective disorder. Therefore, we studied candidate genes in a sample ofunrelated patients (n = 102) and healthy controls (n = 79) of Austrian origin, searching for a possible association between polymorphic DNA markers of 5 candidate genes (serotonin transporter, 5-HTT;serotonin 2a receptor, 5-HT2a; dopamine D2 receptor, DRD2; dopamine D3 receptor, DRD3; dopamine transporter, DAT1) and bipolar disorder. There was an association between allelic and genotypic frequencies of 5-HTT and affection status (p = 0.014 and p= 0.017, respectively). However, after correction for multiple comparisons(Bonferroni), these results did not remain significant. Nevertheless, the findings might suggest that alterations in the structure of 5-HTT are involved in the pathogenesis of bipolar disorder, which could have major implications in treatment. No association between 5-HT2a, DRD2, DRD3, DAT1 and bipolar disorder was found. Copyright (C) 2000 S. Karger AG, Basel.

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Documento generato il 19/01/20 alle ore 20:51:57