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Titolo:
Micro-thermal analysis, FTIR- and Raman-microscopy of (R,S)-proxyphylline crystal forms
Autore:
Griesser, UJ; Auer, ME; Burger, A;
Indirizzi:
Innsbruck Univ, Dept Pharmacognosy, Inst Pharm, A-6020 Innsbruck, Austria Innsbruck Univ Innsbruck Austria A-6020 Pharm, A-6020 Innsbruck, Austria
Titolo Testata:
MICROCHEMICAL JOURNAL
fascicolo: 3, volume: 65, anno: 2000,
pagine: 283 - 292
SICI:
0026-265X(200010)65:3<283:MAFARO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMORPHISM;
Keywords:
(R,S)-proxyphylline; polymorphism; crystal forms; thermal analysis; hot stage microscopy; FTIR-microspectroscopy; Raman-microspectroscopy; X-ray powder diffraction; physical stability;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Griesser, UJ Innsbruck Univ, Dept Pharmacognosy, Inst Pharm, Innrain 52, A-6020 Innsbruck, Austria Innsbruck Univ Innrain 52 Innsbruck Austria A-6020 , Austria
Citazione:
U.J. Griesser et al., "Micro-thermal analysis, FTIR- and Raman-microscopy of (R,S)-proxyphylline crystal forms", MICROCHEM J, 65(3), 2000, pp. 283-292

Abstract

Three modifications of (R,S)-proxyphylline have been characterized by hot stage microscopy, FTIR- and FT-Raman microspectroscopy as well as differential scanning calorimety, X-ray powder diffractometry and helium pycnometry. Mod. I(m.p. 136 degreesC) is thermodynamically stable in the entire temperature range and the only form which crystallizes from organic solvents or water. The metastable mod. II (m.p. 113-116 degreesC) was prepared in gram quantities from the supercooled melt and shows considerable kinetic stability under dry atmospheric conditions. Mod. III (m.p. 82-85 degreesC) is a new, kinetically very unstable form, which can only be produced in microscopicamounts along with mod. II. The metastable forms are monotropically related to mod. I. FTIR- and FT-Raman micro-spectroscopy, in combination with thermal analysis, are demonstrated to be powerful tools for the characterization of microphases and unstable modifications of polymorphic systems, providing information beyond the commonly phenomenological reports on such forms. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 05:08:33