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Titolo:
Role of RT-PCR tyrosinase detection in the monitoring of patients with advanced metastatic melanoma
Autore:
Abate, SO; Savoia, P; Cambieri, I; Salomone, B; Quaglino, P; Bernengo, MG;
Indirizzi:
Univ Turin, Dermatol Clin 1, I-10126 Turin, Italy Univ Turin Turin ItalyI-10126 in, Dermatol Clin 1, I-10126 Turin, Italy Univ Turin, Dept Clin & Surg Specialties, Dermatol Sect, I-10126 Turin, Italy Univ Turin Turin Italy I-10126 ties, Dermatol Sect, I-10126 Turin, Italy
Titolo Testata:
MELANOMA RESEARCH
fascicolo: 6, volume: 10, anno: 2000,
pagine: 545 - 555
SICI:
0960-8931(200012)10:6<545:RORTDI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE-CHAIN-REACTION; MALIGNANT-MELANOMA; PERIPHERAL-BLOOD; MESSENGER-RNA; REVERSE-TRANSCRIPTASE; COMBINATION CHEMOTHERAPY; INTERFERON-ALPHA; CLINICAL STAGE; REACTION ASSAY; CELLS;
Keywords:
circulating melanoma cells; metastatic melanoma; RT-PCR; tyrosinase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Bernengo, MG Univ Turin, Dermatol Clin 1, V Cherasco 23, I-10126 Turin, Italy Univ Turin V Cherasco 23 Turin Italy I-10126 26 Turin, Italy
Citazione:
S.O. Abate et al., "Role of RT-PCR tyrosinase detection in the monitoring of patients with advanced metastatic melanoma", MELANOMA RE, 10(6), 2000, pp. 545-555

Abstract

In recent studies a new method has been proposed to detect circulating melanoma cells in the peripheral blood of patients, based on the amplificationof the mRNA for tyrosinase, an enzyme involved in melanin biosynthesis that is expressed only by melanocytic cells. The sensitivity and clinical relevance of this method are still controversial. In the present study, 596 blood samples from 186 melanoma patients at various clinical tumour stages, together with samples from 25 healthy volunteers, were analysed with the aim of investigating the value of tyrosinase detection in predicting melanoma recurrence. We suggest a possible role for this marker in the monitoring of melanoma patients after the excision of regional lymph node metastases, andprovide evidence that tyrosinase is related to the status of disease in advanced metastatic patients. Moreover, chemotherapy administration appeared to influence tyrosinase determination and may explain the discrepancies in the reported percentages of positive samples. (C) 2000 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 13:35:58