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Titolo:
TRACING THE NA K-ATPASE WITH RUBIDIUM
Autore:
BECK FX; THURAU K;
Indirizzi:
UNIV MUNICH,INST PHYSIOL,DEPT PHYSIOL,PETTENKOFERSTR 12 D-80336 MUNICH GERMANY
Titolo Testata:
Wiener Klinische Wochenschrift
fascicolo: 12-13, volume: 109, anno: 1997,
pagine: 424 - 428
SICI:
0043-5325(1997)109:12-13<424:TTNKWR>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
K-ATPASE; INTERCALATED CELLS; SODIUM-TRANSPORT; COLLECTING DUCT; LOOP DIURETICS; NEPHRON; RAT; EXPRESSION; TUBULE; PRINCIPAL;
Keywords:
NA/K-ATPASE; RUBIDIUM UPTAKE; INTRACELLULAR SODIUM; RENAL TUBULE CELLS; DIURETICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
F.X. Beck e K. Thurau, "TRACING THE NA K-ATPASE WITH RUBIDIUM", Wiener Klinische Wochenschrift, 109(12-13), 1997, pp. 424-428

Abstract

Rubidium (Rb) was used as a marker ion for K to assess Na/K(Rb)-ATPase activity in single renal tubule cells. Initial Rb uptake rates were measured by electron microprobe analysis in individual tubule cells ofthe rat kidney during acute stimulation or during inhibition of transepithelial Na absorption. Under these conditions, Rb uptake closely correlates with intracellular Na concentrations, indicating that the intracellular Na concentration is a major determinant in the precise adjustment of basolateral, Na/K(Rb)-ATPase-dependent Na extrusion to Na entry across the apical cell membrane. Chronically increased distal Na delivery induced by loop diuretics triggers adaptive processes which allow increased transcellular Na movement at normal or near-normal intracellular Na concentrations.

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Documento generato il 20/09/20 alle ore 01:05:27