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Titolo:
The influence of sex and gonadectomy on the growth hormone and corticosterone response to hexarelin in the rat
Autore:
Sibilia, V; Cocchi, D; Pagani, F; Pecile, A; Netti, C;
Indirizzi:
Univ Milan, Dept Pharmacol Chemotherapy & Med Toxicol, I-20129 Milan, Italy Univ Milan Milan Italy I-20129 erapy & Med Toxicol, I-20129 Milan, Italy Univ Brescia, Dept Biomed Sci & Biotechnol, Brescia, Italy Univ Brescia Brescia Italy Dept Biomed Sci & Biotechnol, Brescia, Italy
Titolo Testata:
LIFE SCIENCES
fascicolo: 3, volume: 68, anno: 2000,
pagine: 321 - 329
SICI:
0024-3205(200012)68:3<321:TIOSAG>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
PITUITARY-ADRENAL AXIS; GH-RELEASING ACTIVITY; SEXUALLY DIMORPHIC EXPRESSION; SYNTHETIC HEXAPEPTIDE; SOMATOTROPIC AXIS; GENE-EXPRESSION; SECRETION; SOMATOSTATIN; SECRETAGOGUE; STEROIDS;
Keywords:
hexarelin; growth hormone; corticosterone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Sibilia, V Univ Milan, Dept Pharmacol Chemotherapy & Med Toxicol, Via Vanvitelli 32, I-20129 Milan, Italy Univ Milan Via Vanvitelli 32 Milan Italy I-20129 Milan, Italy
Citazione:
V. Sibilia et al., "The influence of sex and gonadectomy on the growth hormone and corticosterone response to hexarelin in the rat", LIFE SCI, 68(3), 2000, pp. 321-329

Abstract

The present study is designed to investigate the role of sex and gonadal status in the growth hormone (GH) and corticosterone response to hexarelin (HEXA), a GH-releasing peptide, which also causes a stimulatory action on the hypothalamic-pituitary-adrenal (HPA) axis. HEXA (80 mug/Kg) was administered intracarotid to anesthetized intact or gonadectomized male (ORC) and female (OVX) middle-aged rats. The GH stimulatory response to HEXA was gender-related since the GH increase was significantly (p< 0.001) higher in intact males (area under the curve, AUC= 12560 +/- 1784 ng/ml.45 min) than in females (AUC= 4628 +/- 257 ng/ml.45 min). This sex difference does not dependon circulating gonadal steroids since it persists in ORC (AUC = 11980 +/- 1136 ng/ml.45 min) and OVX (AUC = 5539 +/- 614 ng/ml.45 min) rats. The different effects of HEXA on corticosterone secretion detected in male and female rats are probably dependent on the prevailing activity of the HPA axis. In fact, in male rats that have low basal corticosterone levels, HEXA caused an increase in corticosterone secretion, which was significantly (p<.05) higher in ORC than in intact rats. The increase in corticosterone secretionby HEXA both in intact and OVX females was delayed, probably due to the elevated initial corticosterone levels, which could have activated the glucocorticoid negative feedback. We suggest that gender-specific patterns in theregulation of the hypothalamus-pituitary function could be responsible forthe GH and corticosterone sexually differentiated responses to HEXA. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/02/20 alle ore 12:40:16