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Titolo:
Genetic evidence of a role for ATM in functional interaction between humanT-cell leukemia virus type 1 Tax and p53
Autore:
Van, PL; Yim, KW; Jin, DY; Dapolito, G; Kurimasa, A; Jeang, KT;
Indirizzi:
NIAID, Mol Microbiol Lab, NIH, Bethesda, MD 20892 USA NIAID Bethesda MD USA 20892 ol Microbiol Lab, NIH, Bethesda, MD 20892 USA Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Life Sci, Berkeley, CA 94720 USA Univ Calif Berkeley Berkeley CA USA 94720 ife Sci, Berkeley, CA 94720 USA
Titolo Testata:
JOURNAL OF VIROLOGY
fascicolo: 1, volume: 75, anno: 2001,
pagine: 396 - 407
SICI:
0022-538X(200101)75:1<396:GEOARF>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CREB-BINDING-PROTEIN; HTLV-I TAX; TRANSCRIPTIONAL ACTIVATOR TAX; PRIMARY HUMAN-LYMPHOCYTES; TUMOR-SUPPRESSOR PROTEIN; CAMP-RESPONSIVE ELEMENT; LONG TERMINAL REPEAT; WILD-TYPE P53; DNA-DAMAGE; 21-BASE-PAIR REPEATS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
103
Recensione:
Indirizzi per estratti:
Indirizzo: Jeang, KT NIAID, Mol Microbiol Lab, NIH, Bldg 4,Room 306,9000 Rockville Pike, Bethesda, MD 20892 USA NIAID Bldg 4,Room 306,9000 Rockville Pike Bethesda MD USA 20892
Citazione:
P.L. Van et al., "Genetic evidence of a role for ATM in functional interaction between humanT-cell leukemia virus type 1 Tax and p53", J VIROLOGY, 75(1), 2001, pp. 396-407

Abstract

Recent evidence from several investigators suggest that the human T-cell leukemia virus type 1 Tax oncoprotein represses the transcriptional activityof the tumor suppressor protein, p53. An examination of published findingsreveals serious controversy as to the mechanism(s) utilized by Tax to inhibit p53 activity and whether the same mechanism is used by Tax in adherent and suspension cells. Here, we have investigated Tax-p53 interaction simultaneously in adherent epithelial (HeLa and Saos) and suspension T-lymphocyte(Jurkat) cells. Our results indicate that Tax activity through the CREB/CREB-binding protein (CBP), but not NF-kappaB, pathway is needed to repress the transcriptional activity of p53 in all tested cell lines. However, we did find that while CBP binding by Tax is necessary, it is not sufficient forinhibiting p53 function. Based on knockout cell studies, we correlated a strong genetic requirement for the ATM, but not protein kinase-dependent DNA, protein in conferring a Tax-p53-repressive phenotype.

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Documento generato il 19/09/20 alle ore 18:37:34