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Titolo:
Influence of gender and sex hormones on nicotine acute pharmacological effects in mice
Autore:
Damaj, MI;
Indirizzi:
Virginia Commonwealth Univ, Med Coll Virginia, Dept Pharmacol & Toxicol, Richmond, VA 23298 USA Virginia Commonwealth Univ Richmond VA USA 23298 , Richmond, VA 23298 USA
Titolo Testata:
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
fascicolo: 1, volume: 296, anno: 2001,
pagine: 132 - 140
SICI:
0022-3565(200101)296:1<132:IOGASH>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACETYLCHOLINE-RECEPTOR; RATS; ANTINOCICEPTION; SENSITIVITY; INHIBITION; METABOLISM; PREGNANCY; MORPHINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Damaj, MI Virginia Commonwealth Univ, Med Coll Virginia, Dept Pharmacol & Toxicol, Box 980613, Richmond, VA 23298 USA Virginia Commonwealth Univ Box 980613 Richmond VA USA 23298 USA
Citazione:
M.I. Damaj, "Influence of gender and sex hormones on nicotine acute pharmacological effects in mice", J PHARM EXP, 296(1), 2001, pp. 132-140

Abstract

The present study conducted a comprehensive examination of the putative sex differences in the potency of nicotine between male and female ICR mice using several pharmacological and behavioral tests. Among the responses to nicotine where significant sex differences were observed are the antinociceptive and the anxiolytic effects of nicotine. Female mice were found less sensitive to the acute effects of nicotine in these tests after s.c. administration. Similar gender differences were found after i.t. injection. Influence of gonadal hormones could underlie sex differences observed in our studies. Indeed, our data clearly indicate that sex hormones can modulate the effects of nicotine and nicotinic receptors in a differential manner. Progesterone and 17 beta -estradiol were found to block nicotine's antinociceptionin mice. Testosterone failed to do so. In addition, progesterone and 17 beta -estradiol blocked nicotine activation of alpha (4)beta (2) neuronal acetylcholine nicotinic receptors expressed in oocytes. Our findings contribute to our search for receptor mechanisms in drug dependence and in the discovery of better pharmacological agents for nicotine dependence.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 16:39:04