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Titolo:
A peptide derived from activity-dependent neuroprotective protein (ADNP) ameliorates injury response in closed head injury in mice
Autore:
Beni-Adani, L; Gozes, I; Cohen, Y; Assaf, Y; Steingart, RA; Brenneman, DE; Eizenberg, O; Trembolver, V; Shohami, E;
Indirizzi:
Hebrew Univ Jerusalem, Sch Pharm, Dept Pharmacol, Hadassah Med Ctr, IL-91120 Jerusalem, Israel Hebrew Univ Jerusalem Jerusalem Israel IL-91120 -91120 Jerusalem, Israel Hebrew Univ Jerusalem, Hadassah Med Ctr, Dept Neurosurg, IL-91120 Jerusalem, Israel Hebrew Univ Jerusalem Jerusalem Israel IL-91120 -91120 Jerusalem, Israel Tel Aviv Univ, Sackler Fac Exact Sci, Sch Chem, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 h Chem, IL-69978 Tel Aviv, Israel Tel Aviv Univ, Sackler Fac Med, Dept Clin Biochem, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 iochem, IL-69978 Tel Aviv, Israel NICHD, Sect Dev & Mol Pharmacol, Dev Neurobiol Lab, NIH, Bethesda, MD USA NICHD Bethesda MD USA harmacol, Dev Neurobiol Lab, NIH, Bethesda, MD USA
Titolo Testata:
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
fascicolo: 1, volume: 296, anno: 2001,
pagine: 57 - 63
SICI:
0022-3565(200101)296:1<57:APDFAN>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; TRAUMATIC BRAIN INJURY; NEUROTROPHIC FACTOR; AXONAL INJURY; FACTOR-ALPHA; COGNITIVE DEFICITS; ALZHEIMERS-DISEASE; NMDA ANTAGONIST; RAT-BRAIN; TNF-ALPHA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Shohami, E Hebrew Univ Jerusalem, Sch Pharm, Dept Pharmacol, Hadassah Med Ctr, IL-91120 Jerusalem, Israel Hebrew Univ Jerusalem Jerusalem Israel IL-91120 salem, Israel
Citazione:
L. Beni-Adani et al., "A peptide derived from activity-dependent neuroprotective protein (ADNP) ameliorates injury response in closed head injury in mice", J PHARM EXP, 296(1), 2001, pp. 57-63

Abstract

Brain injury induces disruption of the blood-brain barrier, edema, and release of autodestructive factors that produce delayed neuronal damage. NAPSVIPQ (NAP), a femtomolar-acting peptide, is shown to be neuroprotective in amouse model of closed head injury. NAP injection after injury reduced mortality and facilitated neurobehavioral recovery (P< 0.005). Edema was reduced by 70% in the NAP-treated mice (P<0.01). Furthermore, in vivo magnetic resonance imaging demonstrated significant brain-tissue recovery in the NAP-treated animals. NAP treatment decreased tumor necrosis factor-alpha levels in the injured brain and was shown to protect pheochromocytoma (PC12 cells)against tumor necrosis factor-alpha -induced toxicity. Thus, NAP provides significant amelioration from the complex array of injuries elicited by head trauma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:32:28