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Titolo:
Acute effects of 3,4-methylenedioxymethamphetamine alone and in combination with ethanol on the immune system in humans
Autore:
Pacifici, R; Zuccaro, P; Lopez, CH; Pichini, S; Di Carlo, S; Farre, M; Roset, PN; Ortuno, J; Segura, J; De la Torre, R;
Indirizzi:
Inst Municipal Invest Med, Pharmacol Unit, E-08003 Barcelona, Spain Inst Municipal Invest Med Barcelona Spain E-08003 08003 Barcelona, Spain Ist Super Sanita, Dept Clin Biochem, I-00161 Rome, Italy Ist Super SanitaRome Italy I-00161 pt Clin Biochem, I-00161 Rome, Italy Univ Autonoma Barcelona, E-08193 Barcelona, Spain Univ Autonoma BarcelonaBarcelona Spain E-08193 E-08193 Barcelona, Spain Univ Pompeu Fabra, Barcelona, Spain Univ Pompeu Fabra Barcelona SpainUniv Pompeu Fabra, Barcelona, Spain
Titolo Testata:
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
fascicolo: 1, volume: 296, anno: 2001,
pagine: 207 - 215
SICI:
0022-3565(200101)296:1<207:AEO3AA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; KILLER-CELL-ACTIVITY; GROWTH-FACTOR-BETA; COCAINE; NEUROENDOCRINE; CYTOKINES; MDMA; METABOLISM; RESPONSES; ECSTASY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: De la Torre, R Inst Municipal Invest Med, Pharmacol Unit, Doctor Aiguader 80, E-08003 Barcelona, Spain Inst Municipal Invest Med Doctor Aiguader 80 Barcelona Spain E-08003
Citazione:
R. Pacifici et al., "Acute effects of 3,4-methylenedioxymethamphetamine alone and in combination with ethanol on the immune system in humans", J PHARM EXP, 296(1), 2001, pp. 207-215

Abstract

Cell-mediated immune response and release of cytokines after the administration of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") alone and in combination with ethanol were assessed in a double blind, randomized, crossover, controlled clinical trial. Six healthy male recreational users of MDMAparticipated in four different experimental sessions, with a washout interval between sessions of 1 week, in which single oral doses of MDMA (100 mg), ethanol (0.8 g/kg), the combination of both drugs, and placebo were tested. Acute MDMA administration produced a time-dependent immune dysfunction in association with serum concentrations of the drug as well as cortisol stimulation kinetics. Although total leukocyte count remained unchanged, therewas a decrease in the CD4 T/CD8 T-cell ratio due to a decrease in both thepercentage and absolute number of CD4 T-helper cells and simultaneous increase in natural killer (NK) cells. Ethanol consumption produced a decrease in T-helper cells and B lymphocytes. The combination of MDMA and ethanol caused the highest suppressive effect on CD4 T cells and increasing effect inNK cells. Drugs treatment produced a high increase of immunosuppressive cytokines (transforming growth factor-beta and interleukin-10) and a switch from Th1-type cytokines (interleukin-2 and interferon-gamma) to Th2-type cytokines (interleukin-4 and interleukin-10). Disregulation in the production of pro- and anti-inflammatory cytokines with an unbalance toward anti-inflammatory response was also observed. The immune function shows a trend toward baseline levels at 24 h after MDMA kinetics. This transient defect in immunological homeostasis, if temporarily repeated, might alter the immune response with a risk for the general health status.

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Documento generato il 27/01/20 alle ore 08:19:02