Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Bone marrow failure in children with acute liver failure
Autore:
Tung, J; Hadzic, N; Layton, M; Baker, AJ; Dhawan, A; Rela, M; Heaton, ND; Mieli-Vergani, G;
Indirizzi:
Kings Coll Hosp, Dept Child Hlth, London, England Kings Coll Hosp LondonEngland l Hosp, Dept Child Hlth, London, England Kings Coll Hosp, Dept Haematol, London, England Kings Coll Hosp London England oll Hosp, Dept Haematol, London, England Kings Coll Hosp, Dept Transplant Surg, London, England Kings Coll Hosp London England p, Dept Transplant Surg, London, England
Titolo Testata:
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
fascicolo: 5, volume: 31, anno: 2000,
pagine: 557 - 561
SICI:
0277-2116(200011)31:5<557:BMFICW>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEVERE APLASTIC-ANEMIA; PARVOVIRUS B19 INFECTION; FULMINANT HEPATIC-FAILURE; COLONY-STIMULATING FACTOR; SAA WORKING PARTY; ANTILYMPHOCYTE GLOBULIN; ANTITHYMOCYTE GLOBULIN; VIRAL-HEPATITIS; TRANSPLANTATION; CYCLOSPORINE;
Keywords:
acute liver failure; aplastic anemia; hepatitis; parvovirus B19;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Tung, J AI Dupont Hosp Children, POB 269,1600 Rockland Rd, Wilmington, DE 19899 USA AI Dupont Hosp Children POB 269,1600 Rockland Rd Wilmington DE USA 19899
Citazione:
J. Tung et al., "Bone marrow failure in children with acute liver failure", J PED GASTR, 31(5), 2000, pp. 557-561

Abstract

Background: Aplastic anemia is a rare but well-recognized complication of acute hepatitis and acute liver failure. The cause is unknown, and the condition is fatal without bone marrow recovery. Treatment includes immunosuppression regimens or bent: marrow transplantation, The purpose of this study was to investigate the incidence, cause, treatment, and outcomes of this disorder in children. Methods: Retrospective chart review of 75 patients with acute liver failure in a major pediatric liver center. Results: Eight patients had evidence of bone marrow failure. Of those, sixhad aplastic anemia, and two had transient bone marrow suppression. There were five buys, median age 57 months (range, 36-132 months). Two had parvovirus B19, six had non-A, non-B, non-C hepatitis. Five underwent liver transplantation: auxiliary in one, orthotopic in four. The interval between initial symptoms and development of aplastic anemia and/or bone marrow suppression was 21 to 99 days (median, 39 days). Four patients with aplastic anemiareceived intravenous antithymocyte globulin (ATG) or antilymphocyte globulin (ALG). Median recovery period of granulopoiesis was 62 days (range, 27-115 days). Two made a full recovery, one had my elodysplasia, and one with unresponsive disease died of septic complications. Four did not receive ATG/ALG, two had aplastic anemia, and two had bone marrow suppression. Three underwent liver transplantation, and all four resumed granulopoiesis. One child who underwent liver transplantation died of sepsis with chronic rejection. Median recovery of granulopoiesis was 99 days (range, 20-153 days). Conclusions: Bone marrow failure occurs in 10.7% of children with acute liver failure. It sometimes occurs in association with non-A, non-B, non-C hepatitis and parvovirus B19 infection. Treatment with ATG/ALG is successful and is well tolerated in most cases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 12:37:04