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Titolo:
VIP and PACAP 38 modulate ibotenate-induced neuronal heterotopias in the newborn hamster neocortex
Autore:
Gressens, P; Arquie, C; Hill, JM; Marret, S; Sahir, N; Robberecht, P; Evrard, P;
Indirizzi:
Hop Robert Debre, Serv Neuropediat, INSERM E 9935, F-75019 Paris, France Hop Robert Debre Paris France F-75019 SERM E 9935, F-75019 Paris, France Fac Med & Pharm Rouen, MERCI UPRESA 2122, Rouen, France Fac Med & Pharm Rouen Rouen France en, MERCI UPRESA 2122, Rouen, France NICHD, Dev Neurobiol Lab, Sect Dev & Mol Pharmacol, Bethesda, MD USA NICHD Bethesda MD USA ol Lab, Sect Dev & Mol Pharmacol, Bethesda, MD USA Univ Brussels, Sch Med, Lab Chim Biol & Nutr, Brussels, Belgium Univ Brussels Brussels Belgium Lab Chim Biol & Nutr, Brussels, Belgium
Titolo Testata:
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
fascicolo: 12, volume: 59, anno: 2000,
pagine: 1051 - 1062
SICI:
0022-3069(200012)59:12<1051:VAP3MI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOACTIVE-INTESTINAL-PEPTIDE; MURINE DEVELOPING BRAIN; DEVELOPING RAT-BRAIN; PROTEIN-KINASE-C; CEREBRAL-CORTEX; FUNCTIONAL EXPRESSION; EXCITOTOXIC LESIONS; CORTICAL-NEURONS; NMDA RECEPTORS; IN-VITRO;
Keywords:
cAMP; ectopia; excitatory amino acids; N-methyl-D-aspartate; neuronal migration; RO 25-1553;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Gressens, P Hop Robert Debre, Serv Neuropediat, INSERM E 9935, 48 Blvd Serurier, F-75019 Paris, France Hop Robert Debre 48 Blvd Serurier Paris France F-75019 France
Citazione:
P. Gressens et al., "VIP and PACAP 38 modulate ibotenate-induced neuronal heterotopias in the newborn hamster neocortex", J NE EXP NE, 59(12), 2000, pp. 1051-1062

Abstract

Intracerebral administration of ibotenate produces, through activation of N-methyl-D-aspartate (NMDA) receptors, neuronal heterotopias in the newbornhamster neocortex: high doses of ibotenate induce periventricular and subcortical neuronal heterotopias, while low doses of ibotenate produce intracortical heterotopias and molecular layer ectopias. Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) are closely related peptides with neurotrophic properties. They share commonVPAC(1) and VPAC(2) receptors, which use cAMP as a second messenger. Previous studies have shown that VIP prevents excitotoxic neuronal death and exacerbates glutamate-induced c-fos neuronal expression. In order to gain new insight into the molecular control of neuronal migration, the present studyexamined the effects of VIP and PACAP on ibotenate-induced heterotopias inthe newborn hamster. Go-treatment with VIP and a high dose of ibotenate produced a pattern of neuronal heterotopias similar to the one observed in animals treated with low doses of ibotenate alone. Pups co-injected with a low dose of ibotenate and a VIP antagonist displayed cortical dysgeneses similar to those observed in animals treated with high doses of ibotenate alone. The modulating effects of VIP on excitotoxin-induced heterotopias were mimicked by forskolin, PACAP, and by a specific VPAC(2) receptor agonist but not by a VPAC(1) agonist, and were blocked by a protein kinase A (PKA) inhibitor. Taken together, these data suggest that VIP and PAGAP can attenuate ibotenate-induced heterotopias in newborn hamster and that this effect is mediated by the VPAC(2) receptor utilizing the cAMP-PKA pathway.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 07:02:48