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Titolo:
A role for CD21/CD35 and CD19 in responses to acute septic peritonitis: A potential mechanism for mast cell activation
Autore:
Gommerman, JL; Oh, DY; Zhou, XN; Tedder, TF; Maurer, M; Galli, SJ; Carroll, MC;
Indirizzi:
Harvard Univ, Sch Med, Ctr Blood Res, Dept Pathol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 d Res, Dept Pathol, Boston, MA 02115 USA Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Pathol, Boston,MA 02115 USA Harvard Univ Boston MA USA 02115 ed Ctr, Dept Pathol, Boston,MA 02115 USA MIT, Cambridge, MA 02139 USA MIT Cambridge MA USA 02139MIT, Cambridge, MA 02139 USA Duke Univ, Med Ctr, Dept Immunol, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 Med Ctr, Dept Immunol, Durham, NC 27710 USA
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 12, volume: 165, anno: 2000,
pagine: 6915 - 6921
SICI:
0022-1767(200012)165:12<6915:ARFCAC>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
B-LYMPHOCYTE DEVELOPMENT; T-DEPENDENT ANTIGEN; FC-RECEPTORS; COMPLEMENT RECEPTORS; TNF-ALPHA; MICE; EXPRESSION; IMMUNITY; INFECTION; MODULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Carroll, MC Harvard Univ, Sch Med, Ctr Blood Res, Dept Pathol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Pathol, Boston, MA 02115 USA
Citazione:
J.L. Gommerman et al., "A role for CD21/CD35 and CD19 in responses to acute septic peritonitis: A potential mechanism for mast cell activation", J IMMUNOL, 165(12), 2000, pp. 6915-6921

Abstract

Although it is now appreciated that mast cell-mediated release of TNF-alpha is critical for resolution of acute septic peritonitis, questions remain as to how mast cells are activated upon peritoneal bacterial infection, Clues to how this may occur have been derived from earlier studies by Prodeus et al, in which complement proteins C3 and C4 were shown to be required forsurvival following cecal ligation and puncture (CLP), a model for acute septic peritonitis, To evaluate the mechanism for mast cell activation in theCLP model, complement receptor CD21/CD35-deficient mice (Cr2(null)) were examined in the present study, Along with CD19-deficient (CD19(null)) mice, these animals exhibit decreased survival Following CLP compared with wild-type littermates. Injection of IgM before CEP does not change survival ratesfor Cr2(null) mice and only partially improves survival of CD19(null) mice, implicating CD21/CD35 and CD19 in mast cell activation. Interestingly,early TNF-alpha release is also impaired in Cr2(null) and CD19(null) animals, suggesting that these molecules directly affect mast cell activation. Cr2(null) and CD19(null) mice demonstrate an impairment in neutrophil recruitment and a corresponding increase in bacterial load, Examination of peritonealmast cells by flow cytometry and confocal microscopy reveals the expression and colocalization of CD21/CD35 and CD19, Taken together, these findings suggest that the engagement of complement receptors CD21/CD35 along with CD19 on the mast cell surface by C3 fragments may be necessary for the full expression of mast cell activation in the CLP model.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 14:01:58