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Titolo:
Migration and differentiation of autoreactive B-1 cells induced by activated gamma/delta T cells in antierythrocyte immunoglobulin transgenic mice
Autore:
Watanabe, N; Ikuta, K; Fagarasan, S; Yazumi, S; Chiba, T; Honjo, T;
Indirizzi:
Kyoto Univ, Grad Sch Med, Dept Med Chem, Sakyo Ku, Kyoto 6068501, Japan Kyoto Univ Kyoto Japan 6068501 Med Chem, Sakyo Ku, Kyoto 6068501, Japan Kyoto Univ, Grad Sch Med, Dept Gastroenterol, Kyoto 6068501, Japan Kyoto Univ Kyoto Japan 6068501 Dept Gastroenterol, Kyoto 6068501, Japan
Titolo Testata:
JOURNAL OF EXPERIMENTAL MEDICINE
fascicolo: 11, volume: 192, anno: 2000,
pagine: 1577 - 1586
SICI:
0022-1007(200012)192:11<1577:MADOAB>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUTOIMMUNE HEMOLYTIC-ANEMIA; LY-1 B-CELLS; RHEUMATOID-FACTOR; LYMPHOCYTES-T; ANTIGEN; MOUSE; EXPRESSION; RECOGNITION; REPERTOIRE; CHEMOKINES;
Keywords:
RAG2 deficient; gamma/delta TCR transgenic; germinal center; peritoneal cavity; hemolytic anemia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Honjo, T Kyoto Univ, Grad Sch Med, Dept Med Chem, Sakyo Ku, Kyoto 6068501,Japan Kyoto Univ Kyoto Japan 6068501 , Sakyo Ku, Kyoto 6068501, Japan
Citazione:
N. Watanabe et al., "Migration and differentiation of autoreactive B-1 cells induced by activated gamma/delta T cells in antierythrocyte immunoglobulin transgenic mice", J EXP MED, 192(11), 2000, pp. 1577-1586

Abstract

Using normal and transgenic (Tg) mice, we have shown that peritoneal B-1 cells are activated by administration of cytokines or lipopolysaccharide andmigrate to other lymphoid organs where they differentiate into antibody-secreting cells. However, little is known about the process of B-1 cell migration and differentiation in vivo. We developed a mouse line by crossing theantierythrocyte antibody Tg mice (HL mice) with TCR-gamma/delta Tg mice specific for a self-thymus leukemia (TL) antigen in the recombination activating gene (RAG)2(-/-) background. In the presence of the self-antigen, Tg gamma/delta T cells increased in number and manifested activated phenotypes. Peritoneal B-1 cells in these mice migrated into mesenteric lymph nodes anddifferentiated into autoantibody-secreting cells, resulting in strong autoimmune hemolytic anemia. Furthermore, transfer of RAG2(-/-) X HL bone marrow or peritoneal cells into the peritoneal cavity of RAG2(-/-) X TCR-gamma/delta Tg mice gave rise to donor-derived B-1 cells in mesenteric lymph nodes, and these cells produced the autoantibody. Thus, this study demonstrates that the migration of B-1 cells and differentiation into the antibody-secreting cells can be induced by noncognate T cell help and implies the possibility that gamma/delta T cells may induce B-1 cell differentiation in vivo.

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Documento generato il 27/01/20 alle ore 01:35:47