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Titolo:
The effects of electroconvulsive therapy on melatonin
Autore:
Krahn, LE; Gleber, E; Rummans, TA; Pileggi, TS; Lucas, DL; Li, HZ;
Indirizzi:
Mayo Clin, Dept Psychiat, Rochester, MN USA Mayo Clin Rochester MN USAMayo Clin, Dept Psychiat, Rochester, MN USA Mayo Clin, Endocrine Res Unit, Rochester, MN USA Mayo Clin Rochester MN USA o Clin, Endocrine Res Unit, Rochester, MN USA Mayo Clin, Dept Biostat, Rochester, MN USA Mayo Clin Rochester MN USAMayo Clin, Dept Biostat, Rochester, MN USA Univ So Calif, Dept Family Med, Los Angeles, CA USA Univ So Calif Los Angeles CA USA f, Dept Family Med, Los Angeles, CA USA
Titolo Testata:
JOURNAL OF ECT
fascicolo: 4, volume: 16, anno: 2000,
pagine: 391 - 398
SICI:
1095-0680(200012)16:4<391:TEOETO>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
N-ACETYLTRANSFERASE; DEPRESSED-PATIENTS; PLASMA MELATONIN; PINEAL-GLAND; SECRETION; CORTISOL; SUPPRESSION; HUMANS; LIGHT; 6-SULFATOXYMELATONIN;
Keywords:
electroconvulsive therapy; melatonin; 6-sulfatoxymelatonin; major depression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Krahn, LE Mayo Med Sch, 200 1st St SW, Rochester, MN 55902 USA Mayo Med Sch 200 1st St SW Rochester MN USA 55902 , MN 55902 USA
Citazione:
L.E. Krahn et al., "The effects of electroconvulsive therapy on melatonin", J ECT, 16(4), 2000, pp. 391-398

Abstract

Although several studies have investigated the impact of various antidepressant medications on melatonin, there are no published reports addressing the effects of electroconvulsive therapy (ECT). Melatonin's major urinary metabolite, 6-sulfatoxymelatonin (6MT), was measured before and after an acute course of ECT. Fourteen subjects diagnosed with major depression who had failed prior pharmacologic therapy were enrolled. 6MT excretion was measured using an enzyme-linked immunosorbent assay test in 24 hour samples separated into daytime and nighttime components. Hamilton Rating Scale for Depression scores showed a significant improvement (p < 0.0001). Data analysis using the Wilcoxon signed rank test demonstrated a significant decrease in 24hour 6MT post-ECT (p < 0.016) and daytime 6MT (p < 0.008). These results demonstrate an association between a therapeutic response to ECT and decrease in endogenous melatonin production.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 18:21:31