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Titolo:
Neurochemical differentiation of functionally distinct populations of autonomic neurons
Autore:
Anderson, RL; Morris, JL; Gibbins, LL;
Indirizzi:
Flinders Univ S Australia, Dept Anat & Histol, Adelaide, SA 5001, Australia Flinders Univ S Australia Adelaide SA Australia 5001 , SA 5001, Australia Flinders Univ S Australia, Ctr Neurosci, Adelaide, SA 5001, Australia Flinders Univ S Australia Adelaide SA Australia 5001 , SA 5001, Australia
Titolo Testata:
JOURNAL OF COMPARATIVE NEUROLOGY
fascicolo: 3, volume: 429, anno: 2001,
pagine: 419 - 435
SICI:
0021-9967(20010115)429:3<419:NDOFDP>2.0.ZU;2-K
Fonte:
ISI
Lingua:
RUS
Soggetto:
POSTGANGLIONIC SYMPATHETIC NEURONS; SUPERIOR CERVICAL-GANGLION; NEUROPEPTIDE-Y EXPRESSION; HYDROXYLASE MESSENGER-RNA; GUINEA-PIG; CILIARY GANGLION; NERVOUS-SYSTEM; NEUROTRANSMITTER PHENOTYPE; TRANSMITTER PHENOTYPE; DENDRITIC MORPHOLOGY;
Keywords:
sympathetic; neuropeptide Y; somatostatin; guinea pig; coeliac ganglion; immunohistochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Anderson, RL Flinders Univ S Australia, Dept Anat & Histol, GPO Box 2100, Adelaide, SA 5001, Australia Flinders Univ S Australia GPO Box 2100 Adelaide SA Australia 5001
Citazione:
R.L. Anderson et al., "Neurochemical differentiation of functionally distinct populations of autonomic neurons", J COMP NEUR, 429(3), 2001, pp. 419-435

Abstract

The coeliac ganglion of guinea pigs displays a unique topographical arrangement of neurochemically and functionally distinct populations of sympathetic neurons. The authors used multiple-labeling immunohistochemistry to investigate the neurochemical differentiation of these neurons during embryonicand fetal development. Sympathoadrenal precursors, located on either side of the abdominal aorta, were intensely immunoreactive for tyrosine hydroxylase (TH-IR), neurofilament, and the human natural killer 1 antibody at midembryonic stages (Carnegie stages 16-19). During late embryonic stages (stages 20-23), a single bilobed ganglion had formed. At this time, neuropeptideY immunoreactivity (NPY-IR) was widely expressed in sympathetic neurons (with moderate TH-IR) and chromaffin cells (with intense TH-IR). The onset ofsomatostatin (Som-IR) expression followed that of NPY-IR and was restricted to sympathetic neurons. However, at late embryonic stages, most TH-IR neurons with Som-IR also expressed NPY-IR (a combination of peptides not foundin the mature coeliac ganglion). Between late embryonic stages and the endof the early fetal period, there was a significant increase in the proportion of neurons in lateral regions that had both NPY-IR and TH-IR. At the same time, there was an increase in the proportion of neurons in medial regions that had both Som-IR and TH-LR. Neurons expressing both Som-IR and TH-IRwere rarely observed in lateral regions of the coeliac ganglion. Thus, a clear topography within the coeliac ganglion is established during late embryonic and early fetal stages of development and reflects that found in the mature animal by the end of the early fetal period. J. Comp. Neurol. 429:419-435, 2001. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 22:49:56