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Titolo:
Long-term safety and antiretroviral activity of hydroxyurea and didanosinein HIV-infected patients
Autore:
Biron, F; Ponceau, B; Bouhour, D; Boibieux, A; Verrier, B; Peyramond, D;
Indirizzi:
Hop Croix Rousse, Med Ctr Univ, Serv Malad Infect, F-69317 Lyon, France Hop Croix Rousse Lyon France F-69317 Malad Infect, F-69317 Lyon, France bioMerieux, Ctr Natl Rech Sci, Lyon, France bioMerieux Lyon FrancebioMerieux, Ctr Natl Rech Sci, Lyon, France
Titolo Testata:
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
fascicolo: 4, volume: 25, anno: 2000,
pagine: 329 - 336
SICI:
1525-4135(200012)25:4<329:LSAAAO>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS INFECTION; IMMUNE PARAMETERS; CONTROLLED TRIAL; THERAPY; COMBINATION; INDINAVIR; CELL; 2',3'-DIDEOXYINOSINE; LYMPHOCYTES; REPLICATION;
Keywords:
HIV; hydroxyurea; didanosine; long-term efficacy; toxicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Biron, F Hop Croix Rousse, Med Ctr Univ, Serv Malad Infect, 103 Grande RueCroix Rousse, F-69317 Lyon, France Hop Croix Rousse 103 Grande Rue Croix Rousse Lyon France F-69317
Citazione:
F. Biron et al., "Long-term safety and antiretroviral activity of hydroxyurea and didanosinein HIV-infected patients", J ACQ IMM D, 25(4), 2000, pp. 329-336

Abstract

Long-term safety, immunologic effects, and antiretroviral activity of hydroxyurea and didanosine were evaluated in this retrospective study. Some 65 HIV-1-infected patients (39 of whom were antiretroviral naive) were studied(mean baseline CD4 count, 362 cells/mm(3); mean plasma HIV-1 RNA viral load, 4.8 log(10) copies/ mi). The mean treatment duration was 20 months. Overall tolerance was good: 15 patients interrupted treatment because of clinical or biologic side effects. Four patients experienced a category B event. Patients had a mean increase of 27 CD4 cell counts after 12 months, of 112 after 24 months and of 59 after 36 months. They had a mean 1.03 log(10) fall in HIV-1 RNA after 12 months, 1.59 log(10) after 24 months, and 1.27 log(10) after 36 months. After 12 months, 35% developed an HIV-1 RNA viral load<200 copies/ml, 53% after 24 months, and 36% after 36 months. Those whose viral load became undetectable after 12 months have significantly lower baseline RNA values (p =.03). Fourteen patients had a viral load <3.4 log(10) copies/ml after 24 months of the double therapy. A prolonged viral load suppression can be achieved using a simple combination of two drugs that are inexpensive and well tolerated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 10:25:05