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Titolo:
The number of dichorionic twin pregnancies is reduced by the common MTHFR 677C -> T mutation
Autore:
Hasbargen, U; Lohse, P; Thaler, CJ;
Indirizzi:
Univ Munich, Klinikum Grosshadern, Dept Obstet & Gynecol, D-81377 Munich, Germany Univ Munich Munich Germany D-81377 et & Gynecol, D-81377 Munich, Germany Univ Munich, Klinikum Grosshadern, Dept Clin Chem, D-81377 Munich, GermanyUniv Munich Munich Germany D-81377 pt Clin Chem, D-81377 Munich, Germany
Titolo Testata:
HUMAN REPRODUCTION
fascicolo: 12, volume: 15, anno: 2000,
pagine: 2659 - 2662
SICI:
0268-1161(200012)15:12<2659:TNODTP>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYLENETETRAHYDROFOLATE REDUCTASE GENE; RISK FACTOR; FOLATE-DEFICIENCY; DISEASE;
Keywords:
folate metabolism; folic acid deficiency; multiple pregnancy; population genetics; twin rate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Hasbargen, U Univ Munich, Klinikum Grosshadern, Dept Obstet & Gynecol, Marchioninistr 15, D-81377 Munich, Germany Univ Munich Marchioninistr 15 Munich Germany D-81377 Germany
Citazione:
U. Hasbargen et al., "The number of dichorionic twin pregnancies is reduced by the common MTHFR 677C -> T mutation", HUM REPR, 15(12), 2000, pp. 2659-2662

Abstract

In multiple pregnancies, demands for folic acid are considerably increased. The most common inborn error of folate metabolism is mild methylenetetrahydrofolate reductase (MTHFR) deficiency due to the synthesis of a thermolabile variant of the enzyme with impaired catalytic activity which leads to reduced 5-methyltetrahydrofolate (5-methyl-THF) and mildly elevated homocysteine plasma concentrations when folate status is inadequate. To investigatewhether the number of offspring is influenced by this mutation, we determined the frequency of the 677C-->T substitution in 156 singleton and 40 twinmothers with dichorionic placentation, The T allele frequency in singleton(0.30) and twin mothers (0.16) was significantly different (P = 0.011). Mothers with the 677C-->T mutation had a 2.28 times lower risk of having a twin pregnancy than those without (95% confidence interval = 1.18-4.66; P = 0,008), Our observation mould explain, at least in part, the hereditary trait of multiple gestations and is in agreement with the ethnic distribution pattern of the T allele which has been found to be inversely correlated withthe incidence of dichorionic twins. Our findings suggest that the MTHFR 677C-->T mutation interferes with human brood size, probably by influencing the proliferation of rapidly dividing embryonic and maternal cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/10/20 alle ore 01:40:35