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Titolo:
MHC-linked olfactory receptor loci exhibit polymorphism and contribute to extended HLA/OR-haplotypes
Autore:
Ehlers, A; Beck, S; Forbes, SA; Trowsdale, J; Volz, A; Younger, R; Ziegler, A;
Indirizzi:
Humboldt Univ, Klinikum Charite, Inst Immungenet, D-14050 Berlin, Germany Humboldt Univ Berlin Germany D-14050 Immungenet, D-14050 Berlin, Germany Sanger Ctr, Cambridge CB10 1SA, England Sanger Ctr Cambridge England CB10 1SA r Ctr, Cambridge CB10 1SA, England Univ Cambridge, Dept Pathol, Div Immunol, Cambridge CB2 1QP, England Univ Cambridge Cambridge England CB2 1QP nol, Cambridge CB2 1QP, England
Titolo Testata:
GENOME RESEARCH
fascicolo: 12, volume: 10, anno: 2000,
pagine: 1968 - 1978
SICI:
1088-9051(200012)10:12<1968:MORLEP>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAJOR HISTOCOMPATIBILITY COMPLEX; PUTATIVE PHEROMONE RECEPTORS; MATING PREFERENCES; ODORANT RECEPTOR; FUNCTIONAL EXPRESSION; MULTIGENE FAMILY; GENES; MICE; MAMMALS; RECOGNITION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Ziegler, A Humboldt Univ, Klinikum Charite, Inst Immungenet, D-14050 Berlin, Germany Humboldt Univ Berlin Germany D-14050 D-14050 Berlin, Germany
Citazione:
A. Ehlers et al., "MHC-linked olfactory receptor loci exhibit polymorphism and contribute to extended HLA/OR-haplotypes", GENOME RES, 10(12), 2000, pp. 1968-1978

Abstract

Clusters of olfactory receptor [OR] genes are found on most human chromosomes. They are one of the largest mammalian multigene families. Here, we report a systematic study of polymorphism of OR genes belonging to the largestfully sequenced OR cluster. The cluster contains 36 OR genes, of which twobelong to the vomeronasal (VI-OR) family. The cluster is divided into a major and a minor region at the telomeric end of the HLA complex on chromosome 6. These OR genes could be involved in MHC-related mace preferences. The polymorphism screen was carried out with 13 genes from the HLA-linked OR cluster and three genes from chromosomes 7, 17, and 19 as controls. Ten humancell lines, representing 18 different chromosome 6s, were analyzed. They were from various ethnic origins and exhibited different HLA haplotypes. AllOR genes tested, including those not linked to the HLA complex, were polymorphic. These polymorphisms were dispersed along the coding region and resulted in up to seven alleles for a given OR gene. Three polymorphisms resulted either in stop codons (genes hs6M1-4P, hs6M1-17) or in a 16-bp deletion (gene hs6M1-19P), possibly leading to lack of ligand recognition by the respective receptors in the cell line donors. In total, 13 HLA-linked OR haplotypes could be defined, Therefore, allelic variation appears to be a general feature of human OR genes.

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Documento generato il 10/07/20 alle ore 00:20:17