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Titolo:
Fetal obstructive uropathy in trisomy syndromes
Autore:
Qureshi, F; Jacques, SM; Feldman, B; Doss, BJ; Johnson, A; Evans, MI; Johnson, MP;
Indirizzi:
Wayne State Univ, Hutzel Hosp, Sch Med, Dept Pathol, Detroit, MI 48201 USAWayne State Univ Detroit MI USA 48201 Dept Pathol, Detroit, MI 48201 USA
Titolo Testata:
FETAL DIAGNOSIS AND THERAPY
fascicolo: 6, volume: 15, anno: 2000,
pagine: 342 - 347
SICI:
1015-3837(200011/12)15:6<342:FOUITS>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRUNE BELLY SYNDROME; LONG ARM; ASSOCIATION;
Keywords:
aneuploidy; trisomy 21; trisomy 18; fetal obstructive uropathy; prostate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Qureshi, F Wayne State Univ, Hutzel Hosp, Sch Med, Dept Pathol, 4707 St Antoine Blvd,Detroit, MI 48201 USA Wayne State Univ 4707 St Antoine Blvd Detroit MI USA 48201 USA
Citazione:
F. Qureshi et al., "Fetal obstructive uropathy in trisomy syndromes", FETAL DIAGN, 15(6), 2000, pp. 342-347

Abstract

Fetal obstructive uropathy has seldom been described in trisomy syndromes,and its relationship to these syndromes remains unclear. Five trisomic male fetuses, four with trisomy 18 and one with trisomy 21, were identified out of 110 fetuses evaluated for fetal obstructive uropathy. We performed detailed examination on the urinary tracts of four of these fetuses, three with trisomy 18 and one with trisomy 21, following termination in the second trimester. All four had a markedly distended urinary bladder (megacystis), abdominal wall distension, and a small, poorly developed urethra thoughout its full length. All four also had poor development of the prostate with virtual absence of glandular development, as compared to age-matched controls. Posterior urethral valves were not identified in any case. Three of the fetuses (two with trisomy 18 and one with trisomy 21) had unilateral or bilateral hydroureters, and resulting renal tubulocystic or glomerulocystic change. Review of this database reveals an unexpectedly high frequency of trisomies, particularly trisomy 18, suggesting that the relationship may not be coincidental. Abnormal prostate development may be causally related to fetal obstructive uropathies and may be an under-recognized trait in trisomy syndromes. Karyotypic analysis of all fetuses with obstructive uropathy is important since in utero surgical intervention may be contraindicated in cases of fetal aneuploidy. Copyright (C) 2000 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 14:23:42