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Titolo:
Inhibin B response to EFORT is associated with the outcome of oocyte retrieval in the subsequent in vitro fertilization cycle
Autore:
Dzik, A; Lambert-Messerlian, G; Izzo, VM; Soares, JB; Pinotti, JA; Seifer, DB;
Indirizzi:
Brown Univ, Women & Infants Hosp, Sch Med, Dept Pathol & Lab Med, Providence, RI 02903 USA Brown Univ Providence RI USA 02903 ol & Lab Med, Providence, RI 02903 USA Univ Sao Paulo, Hosp Clin, Fac Med, Sao Paulo, Brazil Univ Sao Paulo Sao Paulo Brazil , Hosp Clin, Fac Med, Sao Paulo, Brazil Womens Hosp, Dept Obstet & Gynecol, Sao Paulo, Brazil Womens Hosp Sao Paulo Brazil , Dept Obstet & Gynecol, Sao Paulo, Brazil Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Obstet Gynecol & Reprod Sci, New Brunswick, NJ USA Univ Med & Dent New Jersey New Brunswick NJ USA i, New Brunswick, NJ USA
Titolo Testata:
FERTILITY AND STERILITY
fascicolo: 6, volume: 74, anno: 2000,
pagine: 1114 - 1117
SICI:
0015-0282(200012)74:6<1114:IBRTEI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOLLICLE-STIMULATING-HORMONE; HUMAN MENSTRUAL-CYCLE; OVARIAN RESERVE; DIMERIC INHIBIN; ACTIVIN-A; IN-VITRO; WOMEN; SECRETION; SERUM; FSH;
Keywords:
inhibin B; ovarian reserve; EFORT; estradiol; FSH; IVF;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Lambert-Messerlian, G Brown Univ, Women & Infants Hosp, Sch Med, Dept Pathol & Lab Med, 70 Elm St, Providence, RI 02903 USA Brown Univ 70 Elm St Providence RI USA 02903 903 USA
Citazione:
A. Dzik et al., "Inhibin B response to EFORT is associated with the outcome of oocyte retrieval in the subsequent in vitro fertilization cycle", FERT STERIL, 74(6), 2000, pp. 1114-1117

Abstract

Objective: To examine whether the magnitude of the rise in inhibin B levels after gonadotropin challenge is associated with subsequent response to ovarian stimulation during IVF. Design: Inhibin B serum levels after EFORT (exogenous follicle-stimulatinghormone ovarian reserve test). Setting: Academic clinical practice. Patient(s): Serum samples from women who had undergone ovarian reserve screening with FSH in preparation for IVF. Thirteen of these women had a poor response in IVF (canceled cycle for low estradiol and/or no oocytes retrieved), and 19 had a good response (greater than or equal to 10 oocytes retrieved). Intervention(s): EFORT test. Main Outcome Measure(s): Baseline(day 3) serum E-2 (bE(2)), FSH (bFSH), and inhibin B (bInhB) levels and inhibin B and E-2 levels 24 hours after EFORT (Delta InhB and DeltaE(2)). Result(s): The mean bInhB and Delta InhB levels were significantly higher in good vs. poor responders. The odds ratio of having a good response for women with a Delta InhB of 202 pg/mL was 51.8 times (95% CI = 6.1-1,244) thecorresponding odds for women with a Delta InhB of 49 pg/mL. As expected, DeltaE(2) was also significantly higher in good vs. poor responders; however, combination of DeltaE(2) plus Delta InhB did not improve the odds for predicting IVF response. Conclusion(s): Our data suggest that Delta InhB after EFORT may provide a method for predicting ovarian response to hyperstimulation in a subsequent IVF cycle. (Fertil Steril(R) 2000;74:1114-7. (C) 2000 by American Society for Reproductive Medicine).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 18:32:21