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Titolo:
Selective vulnerability of pallidal neurons in the early phases of manganese intoxication
Autore:
Spadoni, F; Stefani, A; Morello, M; Lavaroni, F; Giacomini, P; Sancesario, G;
Indirizzi:
Univ Roma Tor Vergata, Dipartimento Neurosci, I-00133 Rome, Italy Univ Roma Tor Vergata Rome Italy I-00133 o Neurosci, I-00133 Rome, Italy IRCCS Santa Lucia, I-00179 Rome, Italy IRCCS Santa Lucia Rome Italy I-00179 CS Santa Lucia, I-00179 Rome, Italy Univ Rome La Sapienza, Neurol Clin, I-00149 Rome, Italy Univ Rome La Sapienza Rome Italy I-00149 eurol Clin, I-00149 Rome, Italy
Titolo Testata:
EXPERIMENTAL BRAIN RESEARCH
fascicolo: 4, volume: 135, anno: 2000,
pagine: 544 - 551
SICI:
0014-4819(200012)135:4<544:SVOPNI>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT GLOBUS-PALLIDUS; BASAL GANGLIA; CELL-DEATH; IN-VITRO; NEUROTOXICITY; MITOCHONDRIA; MODULATION; DISORDERS; CURRENTS;
Keywords:
Parkinsonism; perforated-patch; rodents; neurodegeneration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Stefani, A Univ Roma Tor Vergata, Dipartimento Neurosci, Via Tor Vergata 135, I-00133Rome, Italy Univ Roma Tor Vergata Via Tor Vergata 135 Rome Italy I-00133 y
Citazione:
F. Spadoni et al., "Selective vulnerability of pallidal neurons in the early phases of manganese intoxication", EXP BRAIN R, 135(4), 2000, pp. 544-551

Abstract

Prolonged exposure to manganese in mammals may cause an extrapyramidal disorder characterized by dystonia and rigidity. Gliosis in the pallidal segments underlies the well-established phase of the intoxication. The early phase of the intoxication may be characterized by psychic, nonmotor signs, andits morphological and electrophysiological correlates are less defined. Ina rat model of manganese intoxication (20 mg/ml in drinking water for 3 months), neither neuronal loss nor gliosis was detected in globus pallidus (GP). However, a striking vulnerability of manganese-treated GP neurons emerged. The majority of GP neurons isolated from manganese-treated rats died following brief incubation in standard dissociation media. In addition, patch-clamp recordings in the whole-cell configuration were not tolerated by surviving GP neurons. Neither coeval but untreated GP neurons nor striatal ones manifested analogous susceptibility. Using the perforated-patch mode of recording we attempted at identifying the functional hallmarks of GP vulnerability: in particular, voltage-gated calcium currents and glutamate-inducedcurrents were examined. Manganese-treated GP neurons exhibited calcium currents similar to control cells aside from a slight reduction in the dihydropyridine-sensitive current facilitation. Strikingly, manganese-treated GP cells - but not striatal ones - manifested peculiar responses to glutamate, since repeated applications of the excitatory amino acid, at concentrationswhich commonly promote desensitizing responses, produced instead an irreversible cell damage. Possible mechanisms are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 17:14:57