Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Anhydride modified cantharidin analogues. Is ring opening important in theinhibition of protein phosphatase 2A?
Autore:
McCluskey, A; Keane, MA; Mudgee, LM; Sim, ATR; Sakoff, J; Quinn, RJ;
Indirizzi:
Univ Newcastle, Dept Chem, Newcastle, NSW 2308, Australia Univ Newcastle Newcastle NSW Australia 2308 ewcastle, NSW 2308, Australia Univ Newcastle, Discipline Med Biochem, Newcastle, NSW 2308, Australia Univ Newcastle Newcastle NSW Australia 2308 ewcastle, NSW 2308, Australia Newcastle Mater Misericordiae Hosp, Dept Med Oncol, Newcastle, NSW 2301, Australia Newcastle Mater Misericordiae Hosp Newcastle NSW Australia 2301 Australia Griffith Univ, Queensland Pharmaceut Res Inst, Brisbane, Qld 4111, Australia Griffith Univ Brisbane Qld Australia 4111 , Brisbane, Qld 4111, Australia
Titolo Testata:
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
fascicolo: 10, volume: 35, anno: 2000,
pagine: 957 - 964
SICI:
0223-5234(200010)35:10<957:AMCAIR>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
OKADAIC ACID; BINDING; TOPOISOMERASE; DERIVATIVES; FOSTRIECIN; TAUTOMYCIN; PP1;
Keywords:
protein phosphatase 2A; cantharidin; anhydride ring opening;
Tipo documento:
Letter
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: McCluskey, A Univ Newcastle, Dept Chem, Univ Dr, Newcastle, NSW 2308, Australia Univ Newcastle Univ Dr Newcastle NSW Australia 2308 Australia
Citazione:
A. McCluskey et al., "Anhydride modified cantharidin analogues. Is ring opening important in theinhibition of protein phosphatase 2A?", EUR J MED C, 35(10), 2000, pp. 957-964

Abstract

A series of anhydride modified cantharidin analogues have been synthesisedand screened for their ability to inhibit protein phosphatase 2A. Surprisingly only analogues capable of undergoing a facile ring opening of the anhydride moiety displayed any significant inhibition. Subsequent NMR experiments indicated that 7-oxobicyclo[2.2.1]heptane-2,3-dicarboxylic acid was the major (sole) species under assay conditions. The ability of these modified anhydro-cantharidin analogues to inhibit protein phosphatase 2A varies from4 (16) to 100% (8) at 100 muM test concentration. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 13:14:25