Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Expression of N-CAM-180 and N-Cadherin during development in two south-american anuran species (Bufo arenarum and Hyla nana)
Autore:
Izaguirre, MF; Soler, AP; Casco, VH;
Indirizzi:
UNER, Fac Ingn Bioingn, Lab Microscopia, RA-3100 Parana, Entre Rios, Argentina UNER Parana Entre Rios Argentina RA-3100 00 Parana, Entre Rios, Argentina Lankenau Inst Med Res, Wynnewood, PA 19096 USA Lankenau Inst Med Res Wynnewood PA USA 19096 Res, Wynnewood, PA 19096 USA
Titolo Testata:
EUROPEAN JOURNAL OF HISTOCHEMISTRY
fascicolo: 4, volume: 44, anno: 2000,
pagine: 407 - 418
SICI:
1121-760X(2000)44:4<407:EONAND>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-ADHESION MOLECULE; SALAMANDER PLEURODELES-WALTL; ADULT SKELETAL-MUSCLE; XENOPUS EMBRYOS; NEURITE OUTGROWTH; POLYSIALIC ACID; NEUROMUSCULAR-JUNCTION; CAM; HISTOGENESIS; INTEGRINS;
Keywords:
N-CAM-180; N-Cadherin; amphibia; CNS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Casco, VH UNER, Fac Ingn Bioingn, Lab Microscopia, CC 47 Suc 3, RA-3100 Parana, Entre Rios, Argentina UNER CC 47 Suc 3 Parana Entre Rios Argentina RA-3100 , Argentina
Citazione:
M.F. Izaguirre et al., "Expression of N-CAM-180 and N-Cadherin during development in two south-american anuran species (Bufo arenarum and Hyla nana)", EUR J HIST, 44(4), 2000, pp. 407-418

Abstract

Cadherins and N-CAM are Ca++-dependent and Ca++-independent cell adhesion molecules respectively. These molecules play a key role in morphogenesis and histogenesis. We determined the spatiotemporal pattern of N-cadherin and N-CAM-180 kDa expression by immunohistochemistry during development in two South-American anuran species (Bufo arenarum, toad and Hyla nana, frog). Both N-cadherin and N-CAM were not detectable during early developmental stages. Expression of N-cadherin appeared between the inner and the outer ectoderm layers at stages 19-20. At stages 24-25, N-cadherin was expressed inthe neural tube and the heart. In early tadpoles, N-cadherin expression increased along with the central nervous system (CNS) morphogenesis, and reached its maximum level at metamorphic climax stage. N-Cadherin expression was not uniformly distributed. At stage 42, olfactory placodes and retina expressed N-cadherin. Contrary to N-CAM, the strongly myelinated cranial nerves were not labeled. N-Cadherin was present in several mesoderm derivatives such as the notochord, heart and skeletal muscle. The non-neural ectoderm and the endoderm were always negative. Expression of N-CAM appeared first in the neural tube at stages 24-25 and the level of expression became uniform from pre-metamorphic to metamorphic climax tadpoles. At this latter stage, a clear N-CAM immunolabeling appeared in the nerve terminals of pharynx and heart. N-Cadherin and N-CAM were found mainly co-expressed in the CNS from early tadpole to metamorphic climaxtadpole. Our results show that the expression of N-CAM and N-cadherin is evolutionary conserved. Their increased expression during late developmental stages suggests that N-CAM and N-cadherin are involved in cell contact stabilization during tissue formation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 20:16:41