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Titolo:
Non-invasive methods for studying brain energy metabolism: what they show and what it means
Autore:
Kemp, GJ;
Indirizzi:
Univ Liverpool, Dept Musculoskeletal Sci, Liverpool L69 3BX, Merseyside, England Univ Liverpool Liverpool Merseyside England L69 3BX , Merseyside, England
Titolo Testata:
DEVELOPMENTAL NEUROSCIENCE
fascicolo: 5-6, volume: 22, anno: 2000,
pagine: 418 - 428
SICI:
0378-5866(200009/12)22:5-6<418:NMFSBE>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; CEREBRAL BLOOD-FLOW; POSITRON EMISSION TOMOGRAPHY; P-31 MR-SPECTROSCOPY; HUMAN VISUAL-CORTEX; MEASURED IN-VIVO; RAT-BRAIN; OXIDATIVE-METABOLISM; OXYGEN-CONSUMPTION; SKELETAL-MUSCLE;
Keywords:
magnetic resonance spectroscopy; functional magnetic resonance imaging; positron emission tomography; glia; neurons; ATP turnover; metabolic regulation; energy metabolism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
123
Recensione:
Indirizzi per estratti:
Indirizzo: Kemp, GJ Royal Liverpool Univ Hosp, Dept Musculoskeletal Sci, Prescot St, LiverpoolL69 3GA, Merseyside, England Royal Liverpool Univ Hosp Prescot St Liverpool Merseyside England L69 3GA
Citazione:
G.J. Kemp, "Non-invasive methods for studying brain energy metabolism: what they show and what it means", DEV NEUROSC, 22(5-6), 2000, pp. 418-428

Abstract

This review summarises the ways in which magnetic resonance spectroscopy (MRS) and related methods can be used as windows on brain energy metabolism in vivo. P-31-MRS can measure acute changes in non-oxidative ATP synthesis in transient states, and at steady state reflects the balance of ATP demandand mitochondrial function. C-13-MRS labelling methods can measure a variety of carbon fluxes. The few P-31- and C-13-MRS studies of the response to functional activation suggest quite large increases in oxidative metabolism, Functional magnetic resonance imaging measures the hyperoxygenation that results from increase in cerebral blood flow in excess of glucose oxidation, attenuated somewhat by a smaller increase in oxygen consumption. Previouspositron emission tomography studies disagree on the size of activation response, These are powerful but demanding techniques, valuable in understanding both normal physiology and pathophysiology, However, discrepancies remain to be reconciled, and this will require increasing sophistication of both techniques and analytical models. Copyright (C) 2000 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 06:29:04