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Titolo:
The effects of acute antipsychotic drug administration on the neurotensin system of the developing rat brain
Autore:
Kinkead, B; Owens, MJ; Nemeroff, CB;
Indirizzi:
Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Lab Neuropsychopharmacol, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 uropsychopharmacol, Atlanta, GA 30322 USA
Titolo Testata:
DEVELOPMENTAL BRAIN RESEARCH
fascicolo: 1-2, volume: 124, anno: 2000,
pagine: 1 - 10
SICI:
0165-3806(20001130)124:1-2<1:TEOAAD>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONTAINING NEURON SYSTEM; NUCLEUS-ACCUMBENS; MESSENGER-RNA; IMMUNOHISTOCHEMICAL ANALYSIS; ENCODING NEUROTENSIN; POSTNATAL ONTOGENY; NEUROMEDIN-N; DOPAMINE; STRIATUM; RECEPTOR;
Keywords:
schizophrenia; development; haloperidol; ontogeny;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Kinkead, B Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Lab Neuropsychopharmacol, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 armacol, Atlanta, GA 30322 USA
Citazione:
B. Kinkead et al., "The effects of acute antipsychotic drug administration on the neurotensin system of the developing rat brain", DEV BRAIN R, 124(1-2), 2000, pp. 1-10

Abstract

The effects of antipsychotic drugs on the neurotensin (NT) system have been well characterized in adult male animals. There is considerable evidence that the NT system undergoes distinct age-related changes during development of the rat brain. This observation in conjunction with antipsychotic pharmacotherapy in children and breast feeding women led us to characterize theeffects of antipsychotic drug administration in neonatal rats. The effectsof a single subcutaneous injection of haloperidol (2.0 mg/kg) on the developing NT system were determined between postnatal days 10 and 21. Haloperidol significantly increased NT/neuromedin N (NT/NN) mRNA expression and NT concentrations in the caudate/putamen as early as postnatal day 10. Haloperidol did not increase NT/NN mRNA expression in the nucleus accumbens until postnatal day 15 and did not increase NT concentrations in this brain regionuntil postnatal day 21. These results demonstrate that there is a criticallime point in development before which the NT system does not respond to antipsychotic drug administration in the same manner as the mature rat. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:36:05