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Titolo:
Immune cell functions in pancreatic cancer
Autore:
Plate, JMD; Harris, JE;
Indirizzi:
Rush Presbyterian St Lukes Med Ctr, Rush Canc Inst, Sect Med Oncol, Chicago, IL 60612 USA Rush Presbyterian St Lukes Med Ctr Chicago IL USA 60612 ago, IL 60612 USA
Titolo Testata:
CRITICAL REVIEWS IN IMMUNOLOGY
fascicolo: 5, volume: 20, anno: 2000,
pagine: 375 - 392
SICI:
1040-8401(2000)20:5<375:ICFIPC>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOTOXIC T-LYMPHOCYTES; MAJOR HISTOCOMPATIBILITY COMPLEX; TUMOR-INFILTRATING LYMPHOCYTES; POLYMORPHIC EPITHELIAL MUCIN; INTERCELLULAR-ADHESION MOLECULE-1; TANDEM-REPEAT PEPTIDES; FAS LIGAND EXPRESSION; HUMAN RENAL-CELL; CLASS-I; MONOCLONAL-ANTIBODIES;
Keywords:
cytolytic T lymphocytes (CTL); mucin1; tumor antigens; tumor-mediated suppression/inhibition;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
134
Recensione:
Indirizzi per estratti:
Indirizzo: Plate, JMD Rush Presbyterian St Lukes Med Ctr, Rush Canc Inst, Sect Med Oncol, 1653 WCongress Pkwy, Chicago, IL 60612 USA Rush Presbyterian St Lukes Med Ctr 1653 W Congress Pkwy Chicago IL USA 60612
Citazione:
J.M.D. Plate e J.E. Harris, "Immune cell functions in pancreatic cancer", CR R IMMUN, 20(5), 2000, pp. 375-392

Abstract

Pancreatic cancer kills nearly 29,000 people in the United States annually-as many people as are diagnosed with the disease. Chemotherapeutic treatment is ineffective in halting progression of the disease. Yet, specific immunity to pancreatic tumor cells in subjects with pancreatic cancer has been demonstrated repeatedly during the last 24 years. Attempts to expand and enhance tumor-specific immunity with biotherapy, however, have not met with success. The question remains, "Why can't specific immunity regulate pancreatic cancer growth? " The idea that tumor cells have evolved protective mechanisms against immunity was raised years ago and has recently been revisitedby a number of research laboratories. In pancreatic cancer, soluble factors produced by and for the protection of the tumor environment have been detected and are often distributed to the victim's circulatory system where they may effect a more generalized immunosuppression. Yet the nature of thesesoluble factors remains controversial, since some also serve as tumor antigens that are recognized by the same T cells that may become inactivated bythem. Unless the problem of tumor-derived immunosuppressive products is addressed directly through basic and translational research studies, successful biotherapeutic treatment for pancreatic cancer may not be forthcoming.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 01:29:26