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Titolo:
Association of HLA-DRB 1*07 and DRB 1*04 to citrus red mite (Panonychus citri) and house dust mite sensitive asthma
Autore:
Cho, SH; Kim, YK; Oh, HB; Jung, JW; Son, JW; Lee, MH; Jee, HS; Kim, YY; Min, KU;
Indirizzi:
Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul 110744, South Korea Seoul Natl Univ Seoul South Korea 110744 Med, Seoul 110744, South Korea Seoul Natl Univ, Med Res Ctr, Inst Allergy & Clin Immunol, Seoul, South Korea Seoul Natl Univ Seoul South Korea gy & Clin Immunol, Seoul, South Korea Univ Ulsan, Coll Med, Dept Clin Pathol, Seoul, South Korea Univ Ulsan Seoul South Korea Med, Dept Clin Pathol, Seoul, South Korea Cheju Univ, Coll Med, Dept Paediat, Cheju, South Korea Cheju Univ Cheju South Korea Coll Med, Dept Paediat, Cheju, South Korea
Titolo Testata:
CLINICAL AND EXPERIMENTAL ALLERGY
fascicolo: 11, volume: 30, anno: 2000,
pagine: 1568 - 1575
SICI:
0954-7894(200011)30:11<1568:AOH1AD>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRONCHIAL RESPONSIVENESS; IMMUNE RESPONSIVENESS; ATOPIC ASTHMA; ALLERGEN; METHACHOLINE; HAPLOTYPES; POPULATION; RHINITIS; ALLELES; FARMERS;
Keywords:
citrus red mite; asthma; HLA-DRB1; genetic; house dust mite; spider mite;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Min, KU Seoul Natl Univ, Coll Med, Dept Internal Med, 28 Yongon Dong, Seoul 110744, South Korea Seoul Natl Univ 28 Yongon Dong Seoul South Korea 110744 uth Korea
Citazione:
S.H. Cho et al., "Association of HLA-DRB 1*07 and DRB 1*04 to citrus red mite (Panonychus citri) and house dust mite sensitive asthma", CLIN EXP AL, 30(11), 2000, pp. 1568-1575

Abstract

Background Specific IgE responses to allergens provide useful models for evaluating the genetic factors that control human immune responses. A recentsurvey demonstrated that the citrus red mite (Panonychus citri, CRM) is the most important allel gen in the development of asthma in citrus farmers. Objective The aim of this study was to evaluate whether susceptibility or resistance to CRM-induced asthma was associated with HLA-DRB1 gene. Methods DNAs were extracted from two groups of unrelated Korean adults living around citrus farms: (1) Ninety-one adults with CRM-sensitive asthma; and (2) 98 exposed, healthy nonatopic controls. Genotypes of HLA-DRB1 alleles were carried out using PCR-based methods. Results Allelic frequency of HLA-DRB1*07 was higher in the CRM-sensitive asthmatics compared to the controls (17.6% vs 4.1%, Pc = 0.01). Conversely, the frequency of DRB1*04 was lower in the CRM-sensitive asthmatics comparedto the controls (19.8% vs 40.8%, Pc = 0.01). No significant difference wasfound in the distributions of the other HLA-DRB1 gene-encoded antigens between the two groups. Conclusion HLA-DRB1 genes may be involved in the development of CRM-induced asthma. In addition. HLA-DR7 may increase, and DR4 decrease, the risk of developing. the asthma in CRM-exposed adults.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/02/20 alle ore 14:45:34