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Titolo:
Social isolation stress augments angiogenesis induced by colon 26-L5 carcinoma cells in mice
Autore:
Wu, WJ; Murata, J; Murakami, K; Yamaura, T; Hayashi, K; Saiki, I;
Indirizzi:
Toyama Med & Pharmaceut Univ, Inst Nat Med, Dept Pathogen Biochem, Toyama 9300194, Japan Toyama Med & Pharmaceut Univ Toyama Japan 9300194 Toyama 9300194, Japan
Titolo Testata:
CLINICAL & EXPERIMENTAL METASTASIS
fascicolo: 1, volume: 18, anno: 2000,
pagine: 1 - 10
SICI:
0262-0898(2000)18:1<1:SISAAI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; ENDOTHELIAL GROWTH-FACTOR; FACTOR SCATTER FACTOR; SUBSTANCE-P; BREAST-CANCER; ALPHA; INHIBITION; METASTASIS; MACROPHAGES; MECHANISMS;
Keywords:
angiogenesis; colon carcinoma; hepatic sinusoidal endothelial (HSE) cells; tumor necrosis factor-alpha (TNF-alpha); vascular endothelial growth factor (VEGF); hepatocyte growth factor (HGF); social isolation stress;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Saiki, I Toyama Med & Pharmaceut Univ, Inst Nat Med, Dept Pathogen Biochem, 2630 Sugitani, Toyama 9300194, Japan Toyama Med & Pharmaceut Univ 2630 Sugitani Toyama Japan 9300194
Citazione:
W.J. Wu et al., "Social isolation stress augments angiogenesis induced by colon 26-L5 carcinoma cells in mice", CLIN EXP M, 18(1), 2000, pp. 1-10

Abstract

We have previously shown that tumor necrosis factor-alpha (TNF-alpha), which is an important angiogenesis-related factor, was over-secreted in male BALB/c mice under social isolation stress as compared with the control, and closely associated with a remarkable elevation of tumor invasion and metastasis of colon 26-L5 carcinoma cells. In the present study, we explored the effect of isolation stress on the angiogenesis caused by colon 26-L5 carcinoma cells in vivo and in vitro. Social isolation lead to the enhancement oftumor growth after intrahepatic implantation with a fragment of colon 26-L5 tumor. Angiogenic response (number of vessels oriented towards tumor mass) and tumor growth (size) were significantly increased in the socially isolated mouse relative to that in the group-housed mice. Furthermore, higher protein level of hepatic TNF-alpha was found in the stressed mice than that in the control. Expression of mRNA for vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) were also elevated in the tumor regions and liver tissues of the stressed mice in comparison with that in group-housed mice. On the other hand, hepatic sinusoidal endothelial (HSE) cells treated with TNF-alpha exhibited a marked promotion of the migration, invasion, expression of mRNA for matrix metalloproteinase (MMP)-9, and tube-like formation, but no cytotoxicity against the cells in vitro. The above data suggest that the social isolation stress augmented the tumor-induced angiogenesis probably by up-regulating the angiogenesis-related factors, including TNF-alpha, VEGF and HGF, and consequently mediating the functions of endothelial cells such as migration, invasion, and tube-like formation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 06:53:13