Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Ischemia-reperfusion injury at the microvascular level - Treatment by endothelin A-selective antagonist and evaluation by myocardial contrast echocardiography
Autore:
Galiuto, L; DeMaria, AN; del Balzo, U; May-Newman, K; Flaim, SF; Wolf, PL; Kirchengast, M; Iliceto, S;
Indirizzi:
Univ Cagliari, Dept Cardiovasc & Neurol Sci, Cagliari, Italy Univ Cagliari Cagliari Italy t Cardiovasc & Neurol Sci, Cagliari, Italy Univ Calif San Diego, Div Cardiovasc Med, San Diego, CA 92103 USA Univ Calif San Diego San Diego CA USA 92103 Med, San Diego, CA 92103 USA Alliance Pharmaceut Corp, San Diego, CA 92121 USA Alliance Pharmaceut Corp San Diego CA USA 92121 , San Diego, CA 92121 USA Vet Affairs Med Ctr, Dept Pathol, San Diego, CA 92161 USA Vet Affairs Med Ctr San Diego CA USA 92161 athol, San Diego, CA 92161 USA Knoll AG, D-6700 Ludwigshafen, Germany Knoll AG Ludwigshafen Germany D-6700 ll AG, D-6700 Ludwigshafen, Germany
Titolo Testata:
CIRCULATION
fascicolo: 25, volume: 102, anno: 2000,
pagine: 3111 - 3116
SICI:
0009-7322(200012)102:25<3111:IIATML>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
NO-REFLOW PHENOMENON; CORONARY-OCCLUSION; INFARCT SIZE; BLOOD-FLOW; RECEPTOR; DOG; VIABILITY; BQ-123; ARTERY; ETA;
Keywords:
myocardial infarction; ischemia; reperfusion; endothelin; contrast media;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Iliceto, S Univ Cagliari, Dept Cardiovasc & Neurol Sci, Cagliari, Italy Univ Cagliari Cagliari Italy c & Neurol Sci, Cagliari, Italy
Citazione:
L. Galiuto et al., "Ischemia-reperfusion injury at the microvascular level - Treatment by endothelin A-selective antagonist and evaluation by myocardial contrast echocardiography", CIRCULATION, 102(25), 2000, pp. 3111-3116

Abstract

Background-The purpose of this study was to verify whether endothelin A-antagonist administration at the time of coronary reperfusion preserves postischemic microvasculature and whether myocardial contrast echo (MCE) is ableto detect pharmacologically induced changes in microvascular reflow. Methods and Results-Twenty dogs underwent 90 minutes of LAD occlusion (OCC) followed by 180 minutes of reperfusion (RP). Five minutes before LAD reopening, an intravenous bolus (5 mg/kg) of LU 135252 was given in 10 dogs andvehicle in the remaining 10. At baseline (BSL), OCC, and 90 and 180 minutes of RP, microvascular flow (BF) was assessed by microspheres, and MCE was performed with intravenous echo contrast. MCE videointensity and BF were expressed as risk area/control ratio. Myocardial thickness of the risk area was calculated by 2D echo. No differences in BF between the 2 groups were observed at BSL, OCC, and 90 minutes of RP. At 180 minutes of RP, BF was decreased in controls (70+/-4% of BSL; P<0.005 versus BSL) and preserved in LU 135252-treated animals (89+/-4% of BSL; P=NS versus BSL; P<0.05 versus controls). Videointensity at MCE closely followed the changes in BF observed inboth groups throughout the protocol. Myocardial thickness at 180 minutes of RP increased to 138.6+/-9.9% of BSL in controls and remained at 108.9+/-7.4% of BSL in treated dogs (P<0.05). Conclusions-Endothelin A-antagonist treatment at the time of reperfusion significantly limited the progressive decrease in postischemic microvascularreflow and the increase in myocardial thickness. MCE allowed a reliable evaluation of pharmacologically induced changes in microvascular flow.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 09:23:42