Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The noradrenergic alpha 2 agonist clonidine modulates behavioural and neuroanatomical correlates of human attentional orienting and alerting
Autore:
Coull, JT; Nobre, AC; Frith, CD;
Indirizzi:
Inst Neurol, Wellcome Dept Cognit Neurol, London WC1N 3BG, England Inst Neurol London England WC1N 3BG nit Neurol, London WC1N 3BG, England Univ Oxford, Dept Expt Psychol, Oxford OX1 3UD, England Univ Oxford Oxford England OX1 3UD Expt Psychol, Oxford OX1 3UD, England
Titolo Testata:
CEREBRAL CORTEX
fascicolo: 1, volume: 11, anno: 2001,
pagine: 73 - 84
SICI:
1047-3211(200101)11:1<73:TNA2AC>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEFICIT HYPERACTIVITY DISORDER; POSITRON EMISSION TOMOGRAPHY; CORTICAL COGNITIVE FUNCTION; VISUAL-SPATIAL ATTENTION; HEMISPHERIC ASYMMETRIES; VISUOSPATIAL ATTENTION; NEURAL SYSTEMS; WORKING-MEMORY; PERFORMANCE; AROUSAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Coull, JT Inst Neurol, Wellcome Dept Cognit Neurol, 12 Queen Sq, London WC1N 3BG, England Inst Neurol 12 Queen Sq London England WC1N 3BG 1N 3BG, England
Citazione:
J.T. Coull et al., "The noradrenergic alpha 2 agonist clonidine modulates behavioural and neuroanatomical correlates of human attentional orienting and alerting", CEREB CORT, 11(1), 2001, pp. 73-84

Abstract

We examined whether the known noradrenergic attenuation of the alerting effect (the beneficial effect of a warning cue) results from an underlying effect of noradrenaline on temporal orienting (orienting toward a particular moment in time). Following a within-subjects, counterbalanced design, 10 healthy human volunteers received placebo, 200 mug clonidine or 1 mg guanfacine (alpha2 agonists) in three separate testing sessions. Subjects were scanned by fMRI while performing attentional orienting tasks containing spatially informative, temporally informative, non-informative or no cues. The alerting effect primarily activated left-lateralized prefrontal, promotor and parietal regions. Clonidine, but not guanfacine, impaired behavioural measures of the alerting effect while attenuating activity in the left temporo-parietal junction. Replicating previous results, the temporal orienting taskactivated left parietal and frontal cortex, while parietal cortex was activated bilaterally during spatial orienting. Of these networks, clonidine, but not guanfacine, attenuated left prefrontal cortex and insula activity during temporal orienting and attenuated right superior parietal cortex activity during spatial orienting,. To complement these neuroanatomical changes,clonidine produced selective behavioural effects on both temporal and spatial orienting. The anatomical dissociation between the effects of clonidineduring temporal orienting versus alerting suggests that noradrenergic modulation of the alerting effect does not result only from an underlying effect on temporal orienting. Furthermore, we have demonstrated lateralized neuroanatomical substrates for the noradrenergic modulation of human attentional orienting in the spatial and temporal domains.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 11:52:20