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Titolo:
Differences in somatosensory processing in S1 barrel cortex between normaland monoamine oxidase A knockout (Tg8) adult mice
Autore:
Yang, Z; Seif, I; Armstrong-James, M;
Indirizzi:
Univ London Queen Mary & Westfield Coll, St Bartholomews & Royal London Sch Med, Div Biomed Sci, Neurosci Sect, London E1 4NS, England Univ London Queen Mary & Westfield Coll London England E1 4NS S, England Ctr Univ Orsay, Inst Curie, CNRS, U146, F-91405 Orsay, France Ctr Univ Orsay Orsay France F-91405 e, CNRS, U146, F-91405 Orsay, France
Titolo Testata:
CEREBRAL CORTEX
fascicolo: 1, volume: 11, anno: 2001,
pagine: 26 - 36
SICI:
1047-3211(200101)11:1<26:DISPIS>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIAL NUCLEUS VPM; THALAMOCORTICAL AXON TERMINALS; SOMATIC SENSORY RESPONSES; POSTERIOR GROUP POM; NON-NMDA RECEPTORS; MOUSE SML CORTEX; FIELD CORTEX; LAYER-IV; SPATIOTEMPORAL CONVERGENCE; VIBRISSAL INFORMATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Yang, Z Univ London Queen Mary & Westfield Coll, St Bartholomews & Royal London Sch Med, Div Biomed Sci, Neurosci Sect, Mile End Rd, London E1 4NS, England Univ London Queen Mary & Westfield Coll Mile End Rd London England E1 4NS
Citazione:
Z. Yang et al., "Differences in somatosensory processing in S1 barrel cortex between normaland monoamine oxidase A knockout (Tg8) adult mice", CEREB CORT, 11(1), 2001, pp. 26-36

Abstract

Spatio-temporal processing of whisker information was analysed in vivo forsingle neurons in D2 barrel columns of SI cortex in Tg8 mutant mice, whichlack barrels. Findings were compared with normal C3H mice of the same genetic background. The topographical organization of functional columns was similar in Tg8 and normal mice. Response magnitudes (RMs) to D2 principal whisker deflections in D2 columns for Tgs were similar to normals for layers I-III and layer IV cells but short latency responses (>10 ms post-stimulus) were twice the magnitude of normal mice. The surrounding whiskers D1 and D3yielded smaller RMs in layer IV of mutants than normal mice whereas RMs inlayers I-III were equipotent (P > 0.5). Modal latencies were shorter in Tg8 mice in all layers. Latency distributions for whisker D2 responses in both laminae were bimodal in normal mice, peaking at 6-8 and 12 ms post-stimulus, but unimodal in Tg8 mice in both laminae, peaking at 6-8 ms. Hence, despite an absence of barrels, segregation of columns is enhanced in layer IV and sensory processing is faster in layers I-IV compared with normal mice. This contrasts with adenylyl cyclase knockout mice where both an absence ofbarrels and enhanced surrounding whisker responses have been observed. These findings suggest that factors other than barrels and clustering of thalamo-cortical terminals define receptive field geometry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 07:55:53