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Titolo:
Cortical change in Alzheimer's disease detected with a disease-specific population-based brain atlas
Autore:
Thompson, PM; Mega, MS; Woods, RP; Zoumalan, CI; Lindshield, CJ; Blanton, RE; Moussai, J; Holmes, CJ; Cummings, JL; Toga, AW;
Indirizzi:
Univ Calif Los Angeles, Sch Med, Dept Neurol, Lab Neuro Imaging,Div Brain Mapping, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Univ Calif Los Angeles, Sch Med, Alzheimers Dis Ctr, Los Angeles, CA 90024USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024USA
Titolo Testata:
CEREBRAL CORTEX
fascicolo: 1, volume: 11, anno: 2001,
pagine: 1 - 16
SICI:
1047-3211(200101)11:1<1:CCIADD>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
SURFACE-BASED ATLAS; TEMPORAL-LOBE; PROBABILISTIC ATLAS; IMAGE REGISTRATION; COORDINATE SYSTEM; CEREBRAL ATROPHY; CORPUS-CALLOSUM; CENTRAL SULCUS; ASYMMETRY; MRI;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
107
Recensione:
Indirizzi per estratti:
Indirizzo: Thompson, PM Univ Calif Los Angeles, Sch Med, Dept Neurol, Lab Neuro Imaging,Div Brain Mapping, Los Angeles, CA 90024 USA Univ Calif Los Angeles LosAngeles CA USA 90024 CA 90024 USA
Citazione:
P.M. Thompson et al., "Cortical change in Alzheimer's disease detected with a disease-specific population-based brain atlas", CEREB CORT, 11(1), 2001, pp. 1-16

Abstract

We report the first detailed population-based maps of cortical gray matterloss in Alzheimer's disease (AD), revealing prominent features of early structural change. New computational approaches were used to: (i) distinguishvariations in gray matter distribution from variations in gyral patterns; (ii) encode these variations in a brain atlas (n = 46); (iii) create detailed maps localizing gray matter differences across groups. High resolution 3D magnetic resonance imaging (MRI) volumes were acquired from 26 subjects with mild to moderate AD (age 75.8 +/- 1.7 years, MMSE score 20.0 +/- 0.9) and 20 normal elderly controls (72.4 +/- 1.3 years) matched for age, sex, handedness and educational level. Image data were aligned into a standardizedcoordinate space specifically developed for an elderly population. Eighty-four anatomical models per brain, based on parametric surface meshes, were created for all 46 subjects. Structures modeled included: cortical surfaces, all major superficial and deep cortical sulci, callosal and hippocampal surfaces, 14 ventricular regions and 36 gyral boundaries. An elastic warpingapproach, driven by anatomical features, was then used to measure gyral pattern variations. Measures of gray matter distribution were made in corresponding regions of cortex across all 46 subjects. Statistical variations in cortical patterning, asymmetry, gray matter distribution and average gray matter loss were then encoded locally across the cortex. Maps of group differences were generated. Average maps revealed complex profiles of gray matter loss in disease. Greatest deficits (20-30% loss, P < 0.001-0.0001) were mapped in the temporo-parietal cortices. The sensorimotor and occipital cortices were comparatively spared (0-5% loss, P > 0.05). Gray matter loss was greater in the left hemisphere, with different patterns in the heteromodal and idiotypic cortex. Gyral pattern variability also differed in cortical regions appearing at different embryonic phases. 3D mapping revealed profiles of structural deficits consistent with the cognitive, metabolic and histological changes in early AD. These deficits can therefore be (i) charted ina living population and (ii) compared across individuals and groups, facilitating longitudinal, genetic and interventional studies of dementia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 16:25:32