Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
PIKE: A nuclear GTPase that enhances PI3Kinase activity and is regulated by protein 4.1N
Autore:
Ye, KQ; Hurt, J; Wu, FY; Fang, M; Luo, HBR; Hong, JJ; Blackshaw, S; Ferris, CD; Snyder, SH;
Indirizzi:
Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 urosci, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Pharmacol & Mol Sci, Baltimore, MD 21205USA Johns Hopkins Univ Baltimore MD USA 21205 Mol Sci, Baltimore, MD 21205USA Johns Hopkins Univ, Sch Med, Dept Psychiat, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 ychiat, Baltimore, MD 21205 USA
Titolo Testata:
CELL
fascicolo: 6, volume: 103, anno: 2000,
pagine: 919 - 930
SICI:
0092-8674(200012)103:6<919:PANGTE>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; PHOSPHATIDYLINOSITOL KINASE-ACTIVITY; GUANINE-NUCLEOTIDE-EXCHANGE; MITOTIC APPARATUS PROTEIN; HUMAN MXB PROTEIN; PC12 CELLS; NEURITE OUTGROWTH; PHOSPHOINOSITIDE 3-KINASE; CYCLIN D1; ACTIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Snyder, SH Johns Hopkins Univ, Sch Med, Dept Neurosci, 725 N Wolfe St, Baltimore, MD 21205 USA Johns Hopkins Univ 725 N Wolfe St Baltimore MD USA 21205 05 USA
Citazione:
K.Q. Ye et al., "PIKE: A nuclear GTPase that enhances PI3Kinase activity and is regulated by protein 4.1N", CELL, 103(6), 2000, pp. 919-930

Abstract

While cytoplasmic PI3Kinase (P13K) is well characterized, regulation of nuclear P13K has been obscure. A novel protein, PIKE (PI3Kinase Enhancer), interacts with nuclear P13K to stimulate its lipid kinase activity. PIKE encodes a 753 amino acid nuclear GTPase. Dominant-negative PIKE prevents the NGF enhancement of P13K and upregulation of cyclin D1. NGF treatment also leads to PIKE interactions with 4.1N, which has translocated to the nucleus, fitting with the initial identification of PIKE based on its binding 4.1N ina yeast two-hybrid screen. Overexpression of 4.1N abolishes PIKE effects on P13K. Activation of nuclear P13K by PIKE is inhibited by the NGF-stimulated 4.1N translocation to the nucleus. Thus, PIKE physiologically modulates the activation by NGF of nuclear P13K.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/08/20 alle ore 19:56:32