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Titolo:
Delayed F-18-fluoro-2-deoxy-D-glucose positron emission tomography scan for differentiation between malignant and benign lesions in the pancreas
Autore:
Nakamoto, Y; Higashi, T; Sakahara, H; Tamaki, N; Kogire, M; Doi, R; Hosotani, R; Imamura, M; Konishi, J;
Indirizzi:
Kyoto Univ, Grad Sch Med, Dept Nucl Med & Diagnost Imaging, Kyoto, Japan Kyoto Univ Kyoto Japan , Dept Nucl Med & Diagnost Imaging, Kyoto, Japan Kyoto Univ, Grad Sch Med, Dept Surg & Surg Basic Sci, Kyoto, Japan Kyoto Univ Kyoto Japan ch Med, Dept Surg & Surg Basic Sci, Kyoto, Japan Hokkaido Univ, Dept Nucl Med, Sapporo, Hokkaido 060, Japan Hokkaido Univ Sapporo Hokkaido Japan 060 ed, Sapporo, Hokkaido 060, Japan Hamamatsu Univ, Sch Med, Dept Radiol, Hamamatsu, Shizuoka 43131, Japan Hamamatsu Univ Hamamatsu Shizuoka Japan 43131 atsu, Shizuoka 43131, Japan
Titolo Testata:
CANCER
fascicolo: 12, volume: 89, anno: 2000,
pagine: 2547 - 2554
SICI:
0008-543X(200012)89:12<2547:DFPETS>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
F-18 FLUORODEOXYGLUCOSE; FDG-PET; AUTOIMMUNE PANCREATITIS; LIVER METASTASES; CANCER; TUMORS; TISSUE; HEXOKINASE; CARCINOMA; MASSES;
Keywords:
F-18-fluoro-2-deoxy-D-glucose; positron emission tomography; tumors; pancreas; delayed scan;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Nakamoto, Y Kyoto Univ Hosp, Dept Nucl Med, Sakyo Ku, 54 Shogoin Kawahara Cho, Kyoto 6068507, Japan Kyoto Univ Hosp 54 Shogoin Kawahara Cho Kyoto Japan 6068507 n
Citazione:
Y. Nakamoto et al., "Delayed F-18-fluoro-2-deoxy-D-glucose positron emission tomography scan for differentiation between malignant and benign lesions in the pancreas", CANCER, 89(12), 2000, pp. 2547-2554

Abstract

BACKGROUND. Positron emission tomography (PET) using F-18-fluoro-2-deoxy-D-glucose (FDG) has been used for the evaluation of various tumors, but accumulation in inflammatory lesions makes it a controversial modality. The aimof this study was to investigate the usefulness of delayed scanning in differentiation between malignant and benign lesions in the pancreas. METHODS. Forty-seven patients with suspected pancreatic carcinoma were studied by FDG-PET. All patients received approximately 370 megabequerels of FDG after a transmission scan, and an emission scan was performed 1 hour and2 hours later for all patients. A subset of 19 patients was also scanned at 3 hours postinjection. The standardized uptake value (SUV) was determined, and the retention index was calculated by dividing the increase in the SUV between 1 hour and 2 hours postinjection by the SUV at 1 hour postinjection. RESULTS. Of 27 malignant lesions, the SUVs of 22 lesions increased at 2 hours postinjection, whereas the FDG uptake in 17 of 20 benign lesions decreased. The SUVs at 3 hours postinjection were higher than those at 2 hours postinjection in 9 of 14 malignant lesions and in 2 of 5 benign lesions. Malignant lesions showed a higher retention index than benign lesions (mean +/-standard deviation: 12.36 +/- 13.37 and -7.05 +/- 17.28, respectively; P <0.0001). Applying an SUV of 2.5 at 1 hour postinjection with the cut-off value for the differentiation between malignant and benign lesions caused one false negative result and seven false positive results, with a diagnosticaccuracy of 83.0% (39 of 47 patients). However, combining the retention index with the SUV obtained at 2 hours postinjection provided a higher diagnostic accuracy (91.5%; 43 or 47 patients) than the SUV alone. The false negative rate remained constant when the retention index was taken into account. Images at 3 hours postinjection usually were unhelpful in differentiatingfurther between malignant lesions and benign lesions. CONCLUSIONS. The current data suggest that delayed FDG-PET scanning at 2 hours postinjection may contribute to differentiation between malignant and benign lesions in the pancreas. Cancer 2000;89:2547-54. (C) 2000 American Cancer Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:14:06