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Titolo:
The reconstitution of CD45RB(hi)CD4(+) naive T cells is inversely correlated with donor age in murine allogeneic haematopoietic stem cell transplantation
Autore:
Hirayama, M; Azuma, E; Jiang, Q; Kobayashi, M; Iwamoto, S; Kumamoto, T; Kisenge, R; Yamamoto, H; Komada, Y;
Indirizzi:
Mie Univ, Sch Med, Dept Paediat & Clin Immunol, Tsu, Mie 5148507, Japan Mie Univ Tsu Mie Japan 5148507 at & Clin Immunol, Tsu, Mie 5148507, Japan Natl Mie Chuo Hosp, Dept Paediat, Tsu, Mie, Japan Natl Mie Chuo Hosp Tsu Mie Japan huo Hosp, Dept Paediat, Tsu, Mie, Japan
Titolo Testata:
BRITISH JOURNAL OF HAEMATOLOGY
fascicolo: 2, volume: 111, anno: 2000,
pagine: 700 - 707
SICI:
0007-1048(200011)111:2<700:TROCNT>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; CORD-BLOOD TRANSPLANTATION; UNRELATED DONORS; PLACENTAL-BLOOD; HOST DISEASE; HLA-A; RECIPIENTS; ENGRAFTMENT; CHILDREN; LEUKEMIA;
Keywords:
lymphocyte recovery; CD4(+) naive T cells; allogeneic stem cell transplantation; donor age;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Azuma, E Mie Univ, Sch Med, Dept Clin Immunol, 2-174 Edibashi, Tsu, Mie 5148507, Japan Mie Univ 2-174 Edibashi Tsu Mie Japan 5148507 Mie 5148507, Japan
Citazione:
M. Hirayama et al., "The reconstitution of CD45RB(hi)CD4(+) naive T cells is inversely correlated with donor age in murine allogeneic haematopoietic stem cell transplantation", BR J HAEM, 111(2), 2000, pp. 700-707

Abstract

A high incidence of opportunistic infections after unrelated bone marrow transplantation has been reported. Delayed lymphocyte recovery may be associated with opportunistic infections. Immune reconstitution is influenced by recipient age and graft-vs-host disease (GVHD). In fact, children develop GVHD less frequently than adults. However, the role of donor age is largely unknown. We examined the effect of donor age on lymphocyte reconstitution after transplant. Three-month-old BALB/c recipient mice were lethally irradiated and transplanted with allogeneic haematopoietic stem cells from A/J donor mice of different ages, ranging from 0 d to 12 months. The recovery of absolute lymphocyte counts and those of CD3(+) T cells, CD4(+) T cells and CD45RB(hi) CD4(+) naive T cells in the early post-transplant period correlated inversely with donor age. Recipient mice transplanted with haematopoietic stem cells from younger donors showed significantly higher survival rates and mitogenic responses than adult donors. As T cells, especially CD4(+) naive T cells, play an important role in host defence, faster recovery of CD4(+) naive T cells in younger donors may contribute to reduced mortality in the early post-transplant period. The results suggest that it could be better to choose a younger donor if sufficient cell dose is available.

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Documento generato il 08/04/20 alle ore 12:17:44