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Titolo:
Production of soluble CD34 by human myeloid cells
Autore:
Fernandez, M; Simon, V; Minguell, JJ;
Indirizzi:
Univ Chile, Inst Nutr & Tecnol Alimentos, Unidad Biol Celular, Santiago 11, Chile Univ Chile Santiago Chile 11 os, Unidad Biol Celular, Santiago 11, Chile Clin Las Condes, Lab Transplante Medula Osea, Santiago, Chile Clin Las Condes Santiago Chile Transplante Medula Osea, Santiago, Chile
Titolo Testata:
BRITISH JOURNAL OF HAEMATOLOGY
fascicolo: 2, volume: 111, anno: 2000,
pagine: 426 - 431
SICI:
0007-1048(200011)111:2<426:POSCBH>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEMATOPOIETIC STEM-CELLS; HUMAN-BONE-MARROW; PROGENITOR CELLS; ANTIGENIC ANALYSIS; EXPRESSION; MOLECULES; BIOLOGY;
Keywords:
CD34 expression; transmembrane CD34; soluble CD34; myeloid cell lines; human cord blood cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Fernandez, M Univ Chile, Inst Nutr & Tecnol Alimentos, Unidad Biol Celular, Casilla 138, Santiago 11, Chile Univ Chile Casilla 138 Santiago Chile 11 Santiago 11, Chile
Citazione:
M. Fernandez et al., "Production of soluble CD34 by human myeloid cells", BR J HAEM, 111(2), 2000, pp. 426-431

Abstract

CD34, a glycophosphoprotein present in lymphohaematopoietic stem and progenitor cells, as well as in other cell types, exists in both transmembrane and intracytoplasmic forms. Transmembrane CD34 expression, which is high in the earliest haematopoietic precursors, decreases as cells mature. However,to our knowledge, there is no information on whether a decrease in transmembrane CD34 can also predict a release of the molecule from the cell membrane into the extracellular fluid. To investigate the above possibility, we studied conditions (incubation time, cell density and proliferative status) in human myeloid cells (lines KG-1a, KG-1 and cord blood-derived cells) that may cause a decrease in surface CD34 and the generation of a soluble formof the molecule. The latter, as demonstrated by Western blot analysis, adds more complexity to the proposed structural features and functional properties of CD34 in myeloid cells.

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Documento generato il 11/07/20 alle ore 07:51:19