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Titolo:
Engraftment of T-cell-depleted allogeneic haematopoietic stem cells using a reduced intensity conditioning regimen
Autore:
Craddock, C; Bardy, P; Kreiter, S; Johnston, R; Apperley, J; Marks, D; Huber, C; Kolbe, K; Goulding, R; Lawler, M; Goldman, J; Hughes, T; Derigs, G;
Indirizzi:
Queen Elizabeth Hosp, Dept Haematol, Birmingham B15 2TH, W Midlands, England Queen Elizabeth Hosp Birmingham W Midlands England B15 2TH lands, England Hanson Ctr Canc Res, Dept Haematol, Adelaide, SA, Australia Hanson Ctr Canc Res Adelaide SA Australia matol, Adelaide, SA, Australia Univ Mainz, Dept Med 3, D-6500 Mainz, Germany Univ Mainz Mainz Germany D-6500 Mainz, Dept Med 3, D-6500 Mainz, Germany Hammersmith Hosp, Dept Haematol, London, England Hammersmith Hosp LondonEngland th Hosp, Dept Haematol, London, England Bristol Royal Infirm, Dept Haematol, Dublin, Ireland Bristol Royal InfirmDublin Ireland irm, Dept Haematol, Dublin, Ireland St James Hosp, St Patrick Dun Res Labs, Dept Haematol, Dublin, Ireland St James Hosp Dublin Ireland n Res Labs, Dept Haematol, Dublin, Ireland Trinity Coll Dublin, Dublin, Ireland Trinity Coll Dublin Dublin IrelandTrinity Coll Dublin, Dublin, Ireland
Titolo Testata:
BRITISH JOURNAL OF HAEMATOLOGY
fascicolo: 3, volume: 111, anno: 2000,
pagine: 797 - 800
SICI:
0007-1048(200012)111:3<797:EOTAHS>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; GRAFT-VERSUS-LEUKEMIA; MYELOABLATIVE THERAPY; HOST DISEASE; CHIMERISM;
Keywords:
GVHD; stem cell transplantation; T-cell depletion; reduced intensity conditioning;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Craddock, C Queen Elizabeth Hosp, Dept Haematol, Birmingham B15 2TH, W Midlands, England Queen Elizabeth Hosp Birmingham W Midlands England B15 2TH nd
Citazione:
C. Craddock et al., "Engraftment of T-cell-depleted allogeneic haematopoietic stem cells using a reduced intensity conditioning regimen", BR J HAEM, 111(3), 2000, pp. 797-800

Abstract

Graft-versus-host disease (GVHD) remains a significant complication in patients undergoing allogeneic stem cell transplantation (SCT) using a reducedintensity conditioning regimen. Although T-cell depletion (TCD) reduces the risk of GVHD after a myeloablative conditioning regimen, it is associatedwith an increased risk of graft failure. We have therefore examined whether TCD compromises engraftment using a fludarabine-based conditioning regimen. Fifteen patients have been transplanted using such a regimen of whom 13 underwent ex vivo TCD. All but one patient demonstrated durable engraftmentand no patient receiving a TCD product developed severe GVHD. Thus, TCD may play a role in GvHD prophylaxis using such regimens.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 07:01:36