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Titolo:
Movement of zinc and its functional significance in the brain
Autore:
Takeda, A;
Indirizzi:
Univ Shizouka, Sch Pharmaceut Sci, Dept Radiobiochem, Shizouka 4228526, Japan Univ Shizouka Shizouka Japan 4228526 diobiochem, Shizouka 4228526, Japan
Titolo Testata:
BRAIN RESEARCH REVIEWS
fascicolo: 3, volume: 34, anno: 2000,
pagine: 137 - 148
SICI:
0165-0173(200012)34:3<137:MOZAIF>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL-D-ASPARTATE; HIPPOCAMPAL MOSSY FIBERS; CA2+-PERMEABLE AMPA/KAINATE CHANNELS; METALLOTHIONEIN-LIKE PROTEIN; LONG-TERM POTENTIATION; CULTURED RAT NEURONS; A-RECEPTOR COMPLEX; AMINO-ACIDS; CORTICAL-NEURONS; DIETARY ZINC;
Keywords:
zinc metabolism; hippocampus; amygdala; zinc deprivation; zinc-containing glutaminergic neuron;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
206
Recensione:
Indirizzi per estratti:
Indirizzo: Takeda, A Univ Shizouka, Sch Pharmaceut Sci, Dept Radiobiochem, 52-1 Yada,Shizouka 4228526, Japan Univ Shizouka 52-1 Yada Shizouka Japan 4228526 a 4228526, Japan
Citazione:
A. Takeda, "Movement of zinc and its functional significance in the brain", BRAIN RES R, 34(3), 2000, pp. 137-148

Abstract

Zinc, an essential nutrient, is supplied to the brain via both the blood-brain and blood-cerebrospinal fluid barriers. Zinc is most concentrated in the limbic system, i.e. the hippocampus and amygdala, zinc-containing glutaminergic neuron-rich areas. A large portion of zinc serves the function of zinc metalloproteins in neurons and glial cells. In zinc-containing,glutaminergic neurons, vesicular zinc, probably ionic zinc, may serve as an endogenous neuromodulator in synaptic neurotransmission. Vesicular zinc is dynamically coupled to the electrophysiological activity of zinc-containing glutaminergic neurons. Dietary zinc deprivation may influence zinc homeostasis inthe brain, resulting in brain dysfunction such as learning impairment. Excessive excitation of zinc-containing glutaminergic neurons causes a decrease in vesicular zinc, and the decrease might be associated with the susceptibility to seizure. Alteration of zinc levels released into the synaptic cleft may influence neurotransmission in zinc-containing glutaminergic synapses. Therefore, zinc homeostasis in the presynaptic vesicle is important for the function of zinc-containing glutaminergic neurons. (C) 2000 Elsevier Science BN. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:40:02