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Titolo:
Antihyperalgesia effect of BmK IT2, a depressant insect-selective scorpiontoxin in rat by peripheral administration
Autore:
Wang, CY; Tan, ZY; Chen, B; Zhao, ZQ; Ji, YH;
Indirizzi:
Chinese Acad Sci, Shanghai Inst Physiol, Shanghai 200031, Peoples R China Chinese Acad Sci Shanghai Peoples R China 200031 200031, Peoples R China
Titolo Testata:
BRAIN RESEARCH BULLETIN
fascicolo: 3, volume: 53, anno: 2000,
pagine: 335 - 338
SICI:
0361-9230(200010)53:3<335:AEOBIA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSAL-ROOT GANGLIA; SUBUNIT MESSENGER-RNAS; BUTHUS-MARTENSI KARSCH; SODIUM-CHANNELS; NA+ CHANNEL; SENSORY NEURONS; NERVOUS-SYSTEM; TTX-RESISTANT; SMALL-CELLS; VENOM;
Keywords:
scorpion neurotoxin; BmK IT2; paw withdrawal latency; antihyperalgesia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Ji, YH Chinese Acad Sci, Shanghai Inst Physiol, 320 Yue Yang Rd, Shanghai 200031,Peoples R China Chinese Acad Sci 320 Yue Yang Rd Shanghai Peoples RChina 200031 a
Citazione:
C.Y. Wang et al., "Antihyperalgesia effect of BmK IT2, a depressant insect-selective scorpiontoxin in rat by peripheral administration", BRAIN RES B, 53(3), 2000, pp. 335-338

Abstract

The study was undertaken to assess the antihyperalgesia effect of BmK IT2,a sodium channel-specific ligand purified from the venom of Chinese scorpion Buthus martensi Karsch in rat by peripheral injection. The peripheral inflammation of rat was induced by carrageenan resulted in hyperalgesia to heat stimulus. The heat hyperalgesia was measured by paw withdrawal latency (PWL). PWL was increased to 272 +/- 18%, 217 +/- 19% and 186 +/- 16% of the control by application of 10 mul BmK IT2 at the concentration of 0.1, 0.01 and 0.001 mg/ml in inflammatory rats, respectively. In contrast, PWL was enhanced to about 177 +/- 16%, 141 +/- 15% and 133 +/- 15% of the control at the same applied concentrations of BmK IT2 in normal rats. The results thussuggest that BmK IT2 can produce peripheral antihyperalgesia and antinociception, which might be attributed a pathway of modulating the sodium channels on nociceptor. (C) 2000 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 00:06:32