Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Neurokinin A inhibits oxytocin and GABA release from the posterior pituitary by stimulating nitric oxide synthase
Autore:
De Laurentiis, A; Pisera, D; Duvilanski, B; Rettori, V; Lasaga, M; Seilicovich, A;
Indirizzi:
Univ Buenos Aires, Fac Med, Ctr Invest Reprod, RA-1121 Buenos Aires, DF, Argentina Univ Buenos Aires Buenos Aires DF Argentina RA-1121 Aires, DF, Argentina Consejo Nacl Invest Cient & Tecn, Ctr Estudios Farmacol & Bot, Buenos Aires, DF, Argentina Consejo Nacl Invest Cient & Tecn Buenos Aires DF Argentina DF, Argentina
Titolo Testata:
BRAIN RESEARCH BULLETIN
fascicolo: 3, volume: 53, anno: 2000,
pagine: 325 - 330
SICI:
0361-9230(200010)53:3<325:NAIOAG>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-AMINOBUTYRIC-ACID; SIGNAL-TRANSDUCTION MECHANISMS; NADPH-DIAPHORASE; RAT-BRAIN; IN-VIVO; RECEPTORS; NEURONS; HISTOCHEMISTRY; HYPOTHALAMUS; VASOPRESSIN;
Keywords:
neurokinin A; oxytocin; GABA; nitric oxide; posterior pituitary;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Seilicovich, A Univ Buenos Aires, Fac Med, Ctr Invest Reprod, Paraguay 2155,Piso 10, RA-1121 Buenos Aires, DF, Argentina Univ Buenos Aires Paraguay 2155,Piso 10 Buenos Aires DF Argentina RA-1121
Citazione:
A. De Laurentiis et al., "Neurokinin A inhibits oxytocin and GABA release from the posterior pituitary by stimulating nitric oxide synthase", BRAIN RES B, 53(3), 2000, pp. 325-330

Abstract

Neurokinin A (NKA) is a tachykinin that participates in the control of neuroendocrine functions. The posterior pituitary lobe (PP) contains abundant nitric oxide synthase (NOS), suggesting that nitric oxide (NO) may play a role in controlling the release of neuropeptides and neurotransmitters. In the present project, we investigated the in vitro effect of NKA on oxytocin release from hypothalamic explants and PP of male rats and the possible involvement of NO in the action of NKA. Since NKA inhibits gamma -aminobutyricacid (GABA) release from PP, we also examined the role of NO in the effectof NKA on basal and K+-evoked GABA release. NKA (10(-7)-10(-5) M) significantly decreased oxytocin release from PP, whereas it did not affect its release from hypothalamic explants. The inhibitory effect of NKA on oxytocin release from PP was completely blocked by the NOS inhibitors N-G-monomethyl-L-arginine (L-NMMA, 0.5 mM) or N-G-nitro-L-arginine- methyl-ester (L-NAME, 1 mM). Sodium nitroprusside (0.5 mM), an NO releaser, had no effect on basal GABA release but significantly decreased K+-evoked GABA release. L-NMMA (0.3 mM) and L-NAME (0.5 mM) increased K+-evoked GABA release, indicating that NO plays an inhibitory role in GABA release from PR. The inhibition in both basal and K+-evoked GABA release induced by NKA (10(-7) M) was reduced by L-NAME (1 mM). Also, NKA (10-7 M) increased NO synthesis as measured by [C-14] citrulline production. Considered all together, our data indicate that NO may mediate the inhibitory effect of NKA on the release of both oxytocin and GABA from PP. (C) 2000 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 19:40:06