Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Donor leukocyte infusions for multiple myeloma
Autore:
Salama, M; Nevill, T; Marcellus, D; Parker, P; Johnson, M; Kirk, A; Porter, D; Giralt, S; Levine, JE; Drobyski, W; Barrett, AJ; Horowitz, M; Collins, RH;
Indirizzi:
Univ Texas, SW Med Ctr, Dallas, TX 75390 USA Univ Texas Dallas TX USA 75390 iv Texas, SW Med Ctr, Dallas, TX 75390 USA Vancouver Hosp & Hlth Sci Ctr, Vancouver, BC V5Z 1M9, Canada Vancouver Hosp & Hlth Sci Ctr Vancouver BC Canada V5Z 1M9 V5Z 1M9, Canada Johns Hopkins Univ Hosp, Baltimore, MD 21205 USA Johns Hopkins Univ Hosp Baltimore MD USA 21205 p, Baltimore, MD 21205 USA City Hope, Duarte, CA USA City Hope Duarte CA USACity Hope, Duarte, CA USA Baylor Sammons Canc Ctr, Dallas, TX USA Baylor Sammons Canc Ctr Dallas TXUSA r Sammons Canc Ctr, Dallas, TX USA Univ Penn, Sch Med, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 , Sch Med, Philadelphia, PA 19104 USA Univ Texas, MD Anderson Canc Ctr, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 Anderson Canc Ctr, Houston, TX 77030 USA Univ Michigan, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 iv Michigan, Ann Arbor, MI 48109 USA Med Coll Wisconsin, Milwaukee, WI 53226 USA Med Coll Wisconsin Milwaukee WI USA 53226 consin, Milwaukee, WI 53226 USA NHLBI, Bethesda, MD 20892 USA NHLBI Bethesda MD USA 20892NHLBI, Bethesda, MD 20892 USA Med Coll Wisconsin, Int Bone Marrow Transplant Registry, Milwaukee, WI 53226 USA Med Coll Wisconsin Milwaukee WI USA 53226 gistry, Milwaukee, WI 53226 USA
Titolo Testata:
BONE MARROW TRANSPLANTATION
fascicolo: 11, volume: 26, anno: 2000,
pagine: 1179 - 1184
SICI:
0268-3369(200012)26:11<1179:DLIFMM>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; GRAFT-VERSUS-MYELOMA; CHRONIC MYELOGENOUS LEUKEMIA; HOST-DISEASE; ADOPTIVE IMMUNOTHERAPY; LYMPHOCYTE INFUSION; RELAPSE; TRANSFUSIONS; CELLS;
Keywords:
multiple myeloma; donor leukocyte infusions; adoptive immunotherapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Collins, RH Univ Texas, SW Med Ctr, 5323 Harry Hines Blvd, Dallas, TX 75390 USA Univ Texas 5323 Harry Hines Blvd Dallas TX USA 75390 75390 USA
Citazione:
M. Salama et al., "Donor leukocyte infusions for multiple myeloma", BONE MAR TR, 26(11), 2000, pp. 1179-1184

Abstract

Donor leukocyte infusion (DLI) has well-documented activity in CML, but the role of DLI in other diseases is less well defined. To evaluate the strategy in multiple myeloma (MM) we evaluated 25 MM patients from 15 centers who were treated with DLI, Patients with persistent or recurrent disease after allogeneic BMT received DLI from the original marrow donor (23 matched related, one mismatched family, and one matched unrelated). Chemotherapy was given before DLI in three patients, Two of 22 patients responded completelyto DLI alone and three patients responded to the combination of DLI and chemotherapy. Nine patients who had not had sufficient disease control after DLI were given additional DLIs; five of these patients had either complete (two) or partial (three) responses. Thirteen of 25 evaluable patients developed acute GVHD and 11 of 21 evaluable patients developed chronic GVHD; allresponders developed GVHD. No patients developed post-DLI pancytopenia. Four patients had responses which lasted >1 year after DLI, three patients had responses which lasted <1 year, and three patients had ongoing responses but with followup <1 year. In conclusion, DLI has anti-myeloma activity butthe strategy is limited by no response or short duration of response in a significant percentage of patients and by significant GVHD in the majority of the responders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 17:51:03