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Titolo:
Involvement of prolactin-releasing peptide in the preovulatory luteinizinghormone and prolactin surges in the rat
Autore:
Hizume, T; Watanobe, H; Yoneda, M; Suda, T; Schioth, HB;
Indirizzi:
Hirosaki Univ, Sch Med, Dept Internal Med 3, Hirosaki, Aomori 0368562, Japan Hirosaki Univ Hirosaki Aomori Japan 0368562 rosaki, Aomori 0368562, Japan Dokkyo Univ, Sch Med, Dept Gastroenterol, Mibu, Tochigi 3210293, Japan Dokkyo Univ Mibu Tochigi Japan 3210293 erol, Mibu, Tochigi 3210293, Japan Uppsala Univ, BMC, Dept Neurosci, SE-75124 Uppsala, Sweden Uppsala Univ Uppsala Sweden SE-75124 Neurosci, SE-75124 Uppsala, Sweden Melacure Therapeut, Uppsala, Sweden Melacure Therapeut Uppsala SwedenMelacure Therapeut, Uppsala, Sweden
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 1, volume: 279, anno: 2000,
pagine: 35 - 39
SICI:
0006-291X(200012)279:1<35:IOPPIT>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN; RECEPTOR; LEPTIN; PRRP; LOCALIZATION; STIMULATION; EXPRESSION; NEURONS; TISSUE; GENE;
Keywords:
prolactin-releasing peptide; luteinizing hormone; prolactin; surge; normal feeding; fasting; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Watanobe, H Hirosaki Univ, Sch Med, Dept Internal Med 3, 5 Zaifu Cho, Hirosaki, Aomori0368562, Japan Hirosaki Univ 5 Zaifu Cho Hirosaki Aomori Japan 0368562 Japan
Citazione:
T. Hizume et al., "Involvement of prolactin-releasing peptide in the preovulatory luteinizinghormone and prolactin surges in the rat", BIOC BIOP R, 279(1), 2000, pp. 35-39

Abstract

Prolactin (PRL)-releasing peptide (PrRP) is a novel hypothalamic peptide reported as a potent and specific stimulator of PRL secretion. In this study, we examined a possible role of PrRP in the ovarian steroid-induced PRL surge in the rat, simultaneously observing the change in luteinizing hormone (LH) surge. Experiments were performed on both normally-fed and three-day-fasted rats, which were ovariectomized and primed with estradiol and progesterone. From 11:00 to 18:00 h, blood was collected every 30 min to measure LH and PRL. All the following substances were given intracerebroventricularly at 11:00 h. Compared to control serum, anti-rat PrRP31 serum caused a significant reduction of the LH and PRL surges. The antiserum also delayed theonset of PRL surge. Fasted rats were devoid of significant surges of the hormones, while 3.0, but not 0.5 nmol of rat PrRP31 given to these animals produced a significant recovery of PRL surge. Although LH surge was not reinstated, basal LH secretion was transiently stimulated by 3.0 nmol of PrRP31. These results demonstrate for the first time a significant participation of PrRP in the preovulatory LH and PRL surges in the rat. Possible indirectpathways mediating this effect of PrRP were discussed, in view of the unique anatomical distribution of PrRP in the hypothalamus. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 15:33:20