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Titolo:
Epilepsy and the immune system
Autore:
Aarli, JA;
Indirizzi:
Univ Bergen, Haukeland Hosp, Dept Neurol, N-5021 Bergen, Norway Univ Bergen Bergen Norway N-5021 osp, Dept Neurol, N-5021 Bergen, Norway
Titolo Testata:
ARCHIVES OF NEUROLOGY
fascicolo: 12, volume: 57, anno: 2000,
pagine: 1689 - 1692
SICI:
0003-9942(200012)57:12<1689:EATIS>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIPHOSPHOLIPID ANTIBODY SYNDROME; GLUTAMATE-RECEPTOR GLUR3; LANDAU-KLEFFNER SYNDROME; LUPUS-ERYTHEMATOSUS; RASMUSSENS ENCEPHALITIS; GAMMA-GLOBULIN; AUTOANTIBODIES; ASSOCIATION; SEIZURES; CHILDREN;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Aarli, JA Univ Bergen, Haukeland Hosp, Dept Neurol, Jonas Lies 65, N-5021 Bergen, Norway Univ Bergen Jonas Lies 65 Bergen Norway N-5021 1 Bergen, Norway
Citazione:
J.A. Aarli, "Epilepsy and the immune system", ARCH NEUROL, 57(12), 2000, pp. 1689-1692

Abstract

Objective: To discuss evidence that immune mechanisms are involved in the pathogenesis of some forms of epilepsy. Data Sources: Computerized data sources and published indexes and articles. Study Selection: Published reports showing disorders of the immune system in patients with epilepsy and in animals with experimental epilepsy. Data Synthesis: Rasmussen encephalitis is an example of an autoimmune disorder of the central nervous system. Serum samples of patients with this disease contain antibodies to the glutamate receptor GluR3, and immunization of animals with GluR3 induces a disorder resembling the human disease. Thereare still few data to prove that immune mechanisms are involved in the pathogenesis of intractable childhood epilepsies other than Rasmussen encephalitis. Epilepsy is more common in patients with systemic lupus erythematosuswho have antiphospholipid antibodies, and it is possible that these antibodies can lead to immune-mediated cortical damage. Immune defects in patients with epilepsy may occur as a consequence of long-term antiepileptic treatment or may represent a genetic coupling to the convulsive disorder. Conclusion: The finding of an immunological basis may offer new modalitiesfor the treatment of selected cases of intractable partial epilepsies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 09:26:29