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Titolo:
Spectrum of virus inhibition by consensus interferon YM643
Autore:
Yasuda, S; Huffman, JH; Smee, DF; Sidwell, RW; Miyata, K;
Indirizzi:
Yamanouchi Pharmaceut Co Ltd, Inst Drug Discovery Res, Tsukuba, Ibaraki, Japan Yamanouchi Pharmaceut Co Ltd Tsukuba Ibaraki Japan ukuba, Ibaraki, Japan Utah State Univ, Inst Antiviral Res, Logan, UT 84322 USA Utah State Univ Logan UT USA 84322 nst Antiviral Res, Logan, UT 84322 USA
Titolo Testata:
ANTIVIRAL CHEMISTRY & CHEMOTHERAPY
fascicolo: 5, volume: 11, anno: 2000,
pagine: 337 - 341
SICI:
0956-3202(200009)11:5<337:SOVIBC>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC HEPATITIS-C; ALPHA; IFN-ALPHA-CON1; HAMSTERS; ANALOG;
Keywords:
consensus interferon; interferon alfacon-1; interferon-alpha; virus spectrum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Yasuda, S Yamanouchi Pharmaceut Co Ltd, Inst Drug Discovery Res, 21 Miyukigaoka, Tsukuba, Ibaraki, Japan Yamanouchi Pharmaceut Co Ltd 21 Miyukigaoka Tsukuba Ibaraki Japan
Citazione:
S. Yasuda et al., "Spectrum of virus inhibition by consensus interferon YM643", ANTIVIR CHE, 11(5), 2000, pp. 337-341

Abstract

The spectrum of viruses inhibited by a genetically engineered consensus interferon (IFN) YM643 (interferon alfacon-1) was evaluated using a cytopathic effect inhibition assay or plaque inhibition assay for five DNA viruses and 12 RNA viruses. This activity was compared to that of natural IFN-alpha derived from Namalwa lymphoblastoid cell line [IFN-alpha (Namalwa)]. The viruses inhibited by both IFNs were herpesvirus types 1 and 2, human cytomegalovirus, varicella-zoster virus, vesicular stomatitis virus, yellow fever virus, bovine viral diarrhoea virus, Semliki Forest virus, western equine encephalitis virus, encephalomyocarditis virus, rhinovirus type A, respiratory syncytial virus, Newcastle disease virus and influenza virus type A (H1N1). Neither IFN inhibited coxsackie virus B1. reovirus type 3 or vaccinia virus in the experimental conditions used. The specific activity of YM643 in human cells generally ranged from 3.6x10(7) to 2.1x10(9) IU/mg, which was greater than that of IFN-alpha (Namalwa), which ranged from 3.1x10(6) to 4.6x10(8) IU/mg against all sensitive viruses, except human cytomegalovirus and rhinovirus type 1A, which displayed approximately equal sensitivity to both IFNs. Significantly, the potency of YM643 against bovine viral diarrhoeavirus and yellow fever virus, which were selected to serve as surrogates of hepatitis C virus, equalled or exceeded that of IFN-alpha (Namalwa). These results suggest that the genetically engineered YM643 is more potent thannatural IFN-alpha.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 05:50:36