Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Persantine attenuates hemorrhagic shock-induced P-selectin expression
Autore:
Olinde, JG; Zibari, GB; Brown, MF; Howell, JG; Akgur, FM; Granger, DN; McDonald, JC;
Indirizzi:
Louisiana State Univ, Med Ctr, Dept Surg, Shreveport, LA USA Louisiana State Univ Shreveport LA USA tr, Dept Surg, Shreveport, LA USA Louisiana State Univ, Med Ctr, Dept Physiol, Shreveport, LA USA Louisiana State Univ Shreveport LA USA Dept Physiol, Shreveport, LA USA
Titolo Testata:
AMERICAN SURGEON
fascicolo: 12, volume: 66, anno: 2000,
pagine: 1093 - 1097
SICI:
0003-1348(200012)66:12<1093:PAHSPE>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISCHEMIA-REPERFUSION INJURY; ADHERENT LEUKOCYTES; HEPATIC ISCHEMIA; MECHANISMS; ADENOSINE; VENULES; ISCHEMIA/REPERFUSION; RECRUITMENT; PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Zibari, GB Louisiana State Univ, Med Ctr, Div Transplantat, POB 33932, Shreveport, LA71130 USA Louisiana State Univ POB 33932 Shreveport LA USA 711301130 USA
Citazione:
J.G. Olinde et al., "Persantine attenuates hemorrhagic shock-induced P-selectin expression", AM SURG, 66(12), 2000, pp. 1093-1097

Abstract

Ischemia/reperfusion (I/R), a phenomenon that is associated with conditions such as organ transplantation, trauma, vascular disease, and stroke, involves the recruitment of activated and adherent leukocytes that subsequentlymediate tissue injury. Endothelial cell adhesion molecules such as P-selectin mediate I/R-induced leukocyte recruitment and allow the adherent leukocytes to damage the vascular wall and parenchymal cells. This study examinesthe influence of dypiridamole (persantine) on hemorrhagic shock (H/S)-induced P-selectin expression. H/S was induced in C57BL/6 mice by withdrawing blood to drop the mean arterial blood pressure to 30 to 35 mm Hg for 45 minutes. The mice were resuscitated by infusing the shed blood and Ringer's lactate (50% shed blood volume). In vivo P-selectin expression was determined using a dual monoclonal antibody technique in the heart, lung, liver, kidneys, stomach, small bowel, and colon of a control group, a hemorrhagic shockgroup, and a hemorrhagic shock group that was pretreated with Persantine (Boehringer, Ingelheim, Ingelheim, Germany). H/S significantly (P < 0.01) increased P-selectin expression in all regional vascular beds of untreated mice. Persantine treatment largely prevented the H/S-induced P-selectin expression in the same vascular beds. Persantine significantly attenuates the upregulation of P-selectin in the hemorrhagic shock model.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 18:48:01