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Titolo:
Monocyte chemoattractant protein-1 and RANTES are chemotactic for graft infiltrating lymphocytes during acute lung allograft rejection
Autore:
Sekine, Y; Yasufuku, K; Heidler, KM; Cummings, OW; Van Rooijen, N; Fujisawa, T; Brown, J; Wilkes, DS;
Indirizzi:
Indiana Univ, Sch Med, Dept Med, Div Pulm & Crit Care Med, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 re Med, Indianapolis, IN 46202 USA Indiana Univ, Sch Med, Dept Microbiol & Immunol, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 mmunol, Indianapolis, IN 46202 USA Indiana Univ, Sch Med, Dept Pathol, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 Pathol, Indianapolis, IN 46202 USA Indiana Univ, Sch Med, Dept Surg, Indianapolis, IN 46202 USA Indiana UnivIndianapolis IN USA 46202 t Surg, Indianapolis, IN 46202 USA Chiba Univ, Sch Med, Inst Pulm Canc Res, Dept Surg, Chiba 280, Japan ChibaUniv Chiba Japan 280 st Pulm Canc Res, Dept Surg, Chiba 280, Japan Vrije Univ Amsterdam, Fac Med, Dept Cell Biol & Immunol, Amsterdam, Netherlands Vrije Univ Amsterdam Amsterdam Netherlands unol, Amsterdam, Netherlands
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
fascicolo: 6, volume: 23, anno: 2000,
pagine: 719 - 726
SICI:
1044-1549(200012)23:6<719:MCPARA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIAC ALLOGRAFTS; DENDRITIC CELLS; TRANSPLANTATION; MACROPHAGES; CYTOKINES; INFLAMMATION; RECRUITMENT; CHEMOKINES; CLODRONATE; PATHOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Wilkes, DS Indiana Univ, Sch Med, Dept Med, Div Pulm & Crit Care Med, 1001W 10th St,OPW425, Indianapolis, IN 46202 USA Indiana Univ 1001 W 10th St,OPW425 Indianapolis IN USA 46202 SA
Citazione:
Y. Sekine et al., "Monocyte chemoattractant protein-1 and RANTES are chemotactic for graft infiltrating lymphocytes during acute lung allograft rejection", AM J RESP C, 23(6), 2000, pp. 719-726

Abstract

Graft infiltrating lymphocytes (GILs) are crucial to rejection of lung allografts. However, chemotactic activities, chemokines responsible for GIL recruitment, and cells involved in chemokine production during lung allograftrejection have not been evaluated. This study determined whether chemotactic activity for GILs is upregulated, and whether the chemokines monocyte chemoattractant. protein (MCP)-1 and regulated on activation, normal T cells expressed and secreted (RANTES) have roles in GIL chemotaxis during lung allograft rejection. F344 (RT1(lV1)) rat lung allografts were transplanted into WKY (RT1(l)) recipients. Chemotactic activity for GILs and quantities ofMCP-1 and RANTES were determined in allograft bronchoalveolar lavage fluid1 wk after transplantation. Data showed that during rejection, chemotacticactivity for GILs is upregulated, MCP-1 and RANTES are produced locally, and both MCP-1 and RANTES are operative in GIL recruitment. Immunohistochemistry showed that alveolar macrophages (AMs) were the major source of MCP-1 and that other lung cells, including AMs, were the source of RANTES. Further, depletion of AMs in the donor lung before transplantation downregulated chemotaxis for GILs and production of MCP-1 during rejection episodes. These data show that chemotaxis for GILs is upregulated locally during lung allograft rejection, and that MCP-1 and RANTES contribute to GIL recruitment during the rejection response.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 22:46:58