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Titolo:
Uteroplacental insufficiency alters hepatic fatty acid-metabolizing enzymes in juvenile and adult rats
Autore:
Lane, RH; Kelley, DE; Gruetzmacher, EM; Devaskar, SU;
Indirizzi:
Univ Calif Los Angeles, Mattel Childrens Hosp, Sch Med, Dept Pediat, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Pittsburgh, Magee Womens Res Inst, Sch Med, Dept Internal Med, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 nal Med, Pittsburgh, PA 15213 USA Univ Pittsburgh, Magee Womens Res Inst, Sch Med, Dept Pediat, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 Pediat, Pittsburgh, PA 15213 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 1, volume: 280, anno: 2001,
pagine: R183 - R190
SICI:
0363-6119(200101)280:1<R183:UIAHFA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRAUTERINE GROWTH-RETARDATION; FOR-GESTATIONAL-AGE; CARNITINE-PALMITOYLTRANSFERASE-I; PERFORMANCE LIQUID-CHROMATOGRAPHY; ACETYL-COA CARBOXYLASE; GENE-EXPRESSION; BIRTH-WEIGHT; MALONYL-COA; SYNDROME-X; FETAL-RAT;
Keywords:
intrauterine growth retardation; syndrome X; dyslipidemia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Lane, RH Univ Calif Los Angeles, Mattel Childrens Hosp, Sch Med, Dept Pediat, B2-375 MDCC,10833 Le Conte Ave, Los Angeles, CA 90095 USA Univ Calif Los Angeles B2-375 MDCC,10833 Le Conte Ave Los Angeles CA USA 90095
Citazione:
R.H. Lane et al., "Uteroplacental insufficiency alters hepatic fatty acid-metabolizing enzymes in juvenile and adult rats", AM J P-REG, 280(1), 2001, pp. R183-R190

Abstract

Multiple adult morbidities are associated with intrauterine growth retardation (IUGR) including dyslipidemia. We hypothesized that uteroplacental insufficiency and subsequent IUGR in the rat would lead to altered hepatic fatty acid metabolism. To test this hypothesis, we quantified hepatic mRNA levels of acetyl-CoA carboxylase (ACC), carnitine palmitoyltransferase (CPTI),the beta -oxidation-trifunctional protein (HADH), fasting serum triglycerides, and hepatic malonyl-CoA levels at different ages in control and IUGR rats. Fetal gene expression of all three enzymes was decreased. Juvenile gene expression of CPTI and HADH continued to be decreased, whereas gene expression of ACC was increased. Serum triglycerides were unchanged. A sex-specific response was noted in the adult rats. In males, serum triglycerides, hepatic malonyl-CoA levels, and ACC mRNA levels were significantly increased,and CPTI and HADH mRNA levels were significantly decreased. In contrast, the female rats demonstrated no significant changes in these variables. These results suggest that uteroplacental insufficiency leads to altered hepatic fatty acid metabolism that may contribute to the adult dyslipidemia associated with low birth weight.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 05:48:21