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Titolo:
Manipulation of androgens causes different energetic responses to cold in 60-and 40-day-old male rats
Autore:
Gomez, F; Dallman, MF;
Indirizzi:
Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 1, volume: 280, anno: 2001,
pagine: R262 - R273
SICI:
0363-6119(200101)280:1<R262:MOACDE>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
WHITE ADIPOSE-TISSUE; OBESE GENE-PRODUCT; AROMATASE-ACTIVITY; MESSENGER-RNA; ADULT-RATS; BETA-ADRENOCEPTORS; FEMALE RATS; BODY-WEIGHT; FOOD-INTAKE; STRESS;
Keywords:
stress; puberty; body weight; testosterone; leptin; insulin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Dallman, MF Univ Calif San Francisco, Dept Physiol, Box 0444, San Francisco, CA 94143 USA Univ Calif San Francisco Box 0444 San Francisco CA USA 94143 A
Citazione:
F. Gomez e M.F. Dallman, "Manipulation of androgens causes different energetic responses to cold in 60-and 40-day-old male rats", AM J P-REG, 280(1), 2001, pp. R262-R273

Abstract

Previous studies suggested that adults respond differently than pubertal male rats to cold stress. To test the role of androgens in this difference, we adrenalectomized and replaced with corticosterone either 60- or 40-day-old male rats, then sham gonadectomized (Intact), gonadectomized (GDX), or GDX and replaced with testosterone (T; GDX+T) or dihydrotestosterone (DHT). One-half remained at room temperature (RT), and one-half lived in cold for 5 days. Cold reduced T in adult but not in pubertal Intacts. In 60-day-old rats, GDX with or without T replacement had minor effects on body weight (BW) and food intake (FI) at RT and cold. In 40-day-old rats at RT, androgenshad slight effects; however, androgens affected almost all variables in cold. Separation of 40-day-old T-treated rats into two groups (moderate T levels, 1.4 ng/ml; high T levels, 1.9 ng/ml) revealed major differences between the groups. Moderate T (and DHT) prevented cold-induced loss of BW and increased FI. No T and high T induced decreased BW and FI in cold. We conclude that at 40 days of age, partial resistance to stress-induced reduction ofT and high sensitivity to small changes in T have markedly positive effects on threatened energy balance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 00:39:36