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Titolo:
Effect of inhibition of MAO and COMT on intrarenal dopamine and serotonin and on renal function
Autore:
Wang, YQ; Berndt, TJ; Gross, JM; Peterson, MA; So, MJ; Knox, FG;
Indirizzi:
Mayo Clin & Mayo Fdn, Dept Med, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 Med, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn, Dept Physiol & Biophys, Rochester, MN 55905 USA MayoClin & Mayo Fdn Rochester MN USA 55905 phys, Rochester, MN 55905 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 1, volume: 280, anno: 2001,
pagine: R248 - R254
SICI:
0363-6119(200101)280:1<R248:EOIOMA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
CATECHOL-O-METHYLTRANSFERASE; ORGANIC CATION TRANSPORTER; OPOSSUM KIDNEY-CELLS; RAT-KIDNEY; 5-HYDROXYTRYPTAMINE; EXCRETION; EXPRESSION; NATRIURESIS; DERIVATIVES; RECEPTORS;
Keywords:
microdialysis; renal interstitial fluid; phosphate; sodium; glomerular filtration rate; monoamine oxidase; catechol-O-methyltransferase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Knox, FG Mayo Clin & Mayo Fdn, Dept Med, 200 1st St SW, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn 200 1st St SW Rochester MN USA 55905 905 USA
Citazione:
Y.Q. Wang et al., "Effect of inhibition of MAO and COMT on intrarenal dopamine and serotonin and on renal function", AM J P-REG, 280(1), 2001, pp. R248-R254

Abstract

The purpose of the present investigation was to study the effects of inhibition of monoamine oxidase (MAO) and/or catechol-O-methyltransferase (COMT), enzymes involved in the degradation of dopamine (DA) and serotonin (5-HT), on intrarenal DA and 5-HT, as reflected in the renal interstitial fluid (RIF) microdialysate and urine, and on renal function. Inhibition of MAO selectively increased RIF 5-HT from 3.16 +/- 0.38 to 8.03 +/- 1.83 pg/min (n =7, P < 0.05), concomitant with decreases in mean arterial blood pressure and glomerular filtration rate (2.09 +/- 0.18 to 1.57 +/- 0.22 ml/min, n = 7, P < 0.05). Inhibition of COMT significantly increased RIF DA (3.47 +/- 0.70 to 8.68 +/- 1.96 pg/min, n = 9, P < 0.05), urinary DA (2.00 +/- 0.16 to 2.76 +/- 0.26 ng/min, n = 9, P < 0.05), and absolute excretion of sodium (6.42 +/- 2.00 to 9.82 +/- 1.62 mmol/min, n = 10, P < 0.05). Combined inhibition of MAO and COMT significantly increased RIF DA, urinary DA, and urinary5-HT, which was accompanied with increases in urine flow rate, and absolute (3.03 +/- 0.59 to 8.40 +/- 1.61 mmol/min, n = 9, P < 0.01) and fractionalexcretion of sodium. We conclude that inhibition of MAO selectively increases RIF 5-HT. COMT appears to be more important than MAO in the metabolism of intrarenal DA. Physiological increases in intrarenal DA/5-HT induced by inhibition of their degrading enzymes are accompanied with significant alterations of renal function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 06:45:50