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Titolo:
Glutathione attenuates coronary constriction to acetylcholine in patients with coronary spastic angina
Autore:
Kugiyama, K; Miyao, Y; Sakamoto, T; Kawano, H; Soejima, H; Miyamoto, S; Yoshimura, M; Ogawa, H; Sugiyama, S; Yasue, H;
Indirizzi:
Kumamoto Univ, Sch Med, Dept Cardiovasc Med, Kumamoto 8608556, Japan Kumamoto Univ Kumamoto Japan 8608556 iovasc Med, Kumamoto 8608556, Japan
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 1, volume: 280, anno: 2001,
pagine: H264 - H271
SICI:
0363-6135(200101)280:1<H264:GACCTA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
REVERSES ENDOTHELIAL DYSFUNCTION; NITRIC-OXIDE; ARTERIES; CIRCULATION; SMOKING; PLASMA;
Keywords:
coronary vasospasm; endothelial function; free radicals;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Kugiyama, K Kumamoto Univ, Sch Med, Dept Cardiovasc Med, Honjo 1-1-1, Kumamoto 8608556, Japan Kumamoto Univ Honjo 1-1-1 Kumamoto Japan 8608556 08556, Japan
Citazione:
K. Kugiyama et al., "Glutathione attenuates coronary constriction to acetylcholine in patients with coronary spastic angina", AM J P-HEAR, 280(1), 2001, pp. H264-H271

Abstract

This study examined the effect of reduced glutathione (GSH), an important antioxidant that restores intracellular redox imbalance and prevents inactivation of endothelial-derived nitric oxide, on the abnormal vasomotor reactivity in spastic coronary arteries. The responses of epicardial diameter ofthe left coronary arteries to intracoronary infusion of acetylcholine (ACh; 50 mug/min) were measured by quantitative coronary angiography before andduring combined intracoronary infusion of GSH (50 mg/min for 6 min) or saline as a placebo in 24 patients with coronary spastic angina and in 28 control patients. All of the spastic coronary arteries showed constrictor response to ACh, whereas the control coronary arteries as a whole showed only minimal diameter changes to ACh. GSH infusion suppressed constrictor responseof epicardial diameter to ACh in patients with coronary spastic angina, whereas it had no significant effect in control subjects. Saline infusion didnot have any effects. The results indicate that GSH attenuated the constrictor response to ACh in epicardial coronary arteries of patients with coronary spastic angina. GSH may have an important role in the regulation of coronary vasomotor function in patients with coronary spastic angina.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 11:48:18